[A rare case of Gardner's syndrome complicated with rectal carcinoma].

Gardner's syndrome is a rare variant of the Familial Adenomatous Polyposis (FAP) in which affected individuals develop thousands of polyps within the gastrointestinal tract, with a 100 % risk of eventual malignant change. They also have a variety of extraintestinal abnormalities - various soft and hard tissues tumors like fibroma, osteoma, epidermoid cysts, sebaceous cysts on the scalp. Gardner's syndrome is an autosomal dominant disease, caused by mutations in APC ( adenomatous polyposis coli ) gene, which is located in chromosomal locus 5q21- q22.

[Diagnostic possibilities of the flexible hysteroscopy in irregular uterine bleeding].

The aim of the present study was to evaluate the possibilities of diagnostic flexible hysteroscopy for women with irregular uterine bleeding. The study was based on 569 women aged between 26 and 72 years (mean age 46.78 years) with weak to moderate irregular uterine bleeding who had given agreement for invasive investigations.

[Polyposis of the colon and cancer].

Polyposis of the colon is a colon cancer predisposition syndrome. Familial adenomatous polyposis (FAP) accounts for 1% of the cases of inherited colorectal cancer (CRC). The National Register of inherited CRC and polyposis of the intestines keeps track of 18 patients from 14 families with FAP.

[Our experience with the LEEP/LLETZ technique in the diagnostics and treatment of the precancer lesions of the uterine cervix].

The aim of the present study was to asses the possibilities of the LEEP/LLETZ technique at the diagnostics and treatment of the precancer lesions of the uterine cervix. For the period 2000-2004, the study involved 114 women, aged between 17-68 years (mean 38.4) with different grades of cytological, colposcopical and histological abnormalities.

[Is the directed biopsy accurate?].

The aim of the present study was to evaluate the diagnostic accuracy of the colposcopically directed biopsy of cytologically signalized women. Retrospectively were analyzed sixty women aged between 20 and 69 (mean 37.4), to whom was performed colposcopically directed biopsy and consequent in the interval of no more than 3 months extended excision (to 30 of them--surgical conisation and to another 30--LLETZ/LEEP).