The spatial configuration of local climate zones reveals effects on wayfinding in human walking.

The importance of easy wayfinding in complex urban settings has been recognized in spatial planning. Empirical measurement and explicit representation of wayfinding, however, have been limited in deciding spatial configurations. Our study proposed and tested an approach to improving wayfinding by incorporating spatial analysis of urban forms in the Guangdong-Hong Kong-Macau Great Bay Area in China.

Association of Gut and Chronic Spontaneous Urticaria.

(1) Background: Chronic spontaneous urticaria (CSU) has been linked to the dysbiosis of the gut microbiota. Furthermore, various studies have highlighted the anti-inflammatory properties of short-chain fatty acids (SCFAs), whose production is primarily regulated by the gut microbiota. However, only a few studies have investigated the role of major SCFA producers, such as , in skin inflammatory diseases.

Water quality management at a critical checkpoint by coordinated multi-catchment urban-rural load allocation.

Improving river water quality at critical checkpoints, defined as locations with significant impacts on water use, to satisfy regulation standards is an important goal of sustainable catchment management. Challenges remain in investigating pollution hotspots, designing efficient target reduction, and evaluating management performance. To address these challenges, we develop a systems approach for water quality management that integrates natural physical processes with human activities and their environmental impacts.

Optimisation of urban-rural nature-based solutions for integrated catchment water management.

Nature-based solutions (NBS) have co-benefits for water availability, water quality, and flood management. However, searching for optimal integrated urban-rural NBS planning to maximise co-benefits at a catchment scale is still limited by fragmented evaluation. This study develops an integrated urban-rural NBS planning optimisation framework based on the CatchWat-SD model, which is developed to simulate a multi-catchment integrated water cycle in the Norfolk region, UK.

Liver transplantation in hepatocellular carcinoma - should we perform downstaging?

Aim: To compare the long-term outcomes between liver transplant (LT) recipients with hepatocellular carcinoma (HCC) who were downstaged with transarterial-chemoembolization (TACE) to the Milan criteria (MC) and those initially meeting the MC.

Methods: This retrospective study enrolled 198 patients with HCC: 38 were downstaged and 160 patients initially met the MC. Post-LT survival and HCC recurrence-free survival were evaluated.