Publications by authors named "A Michielan"
Article Synopsis
- Motorized spiral enteroscopy (MSE) is a new and advanced medical technique used to examine the intestines using special devices.
- However, it was withdrawn from the market because of safety concerns, particularly related to injuries in the throat, even though it showed good results in helping doctors diagnose and treat problems.
- A study in Italy aimed to test MSE's effectiveness and safety but had to stop early when the technique was removed from use; the study found that MSE could still be useful as a backup method if other techniques fail.
Background: Therapeutic approach used for pancreatic ductal adenocarcinoma is usually translated also for the rarer acinar counterpart, which shows a different mutational landscape nevertheless. While dMMR/MSI-H status is rare in the ductal histotype, it appears to be more prevalent in pancreatic acinar cell carcinoma (PACC).
Case Presentation: We report the case of a patient with locally advanced MSI-H PACC in whom the treatment with the anti-PD-1 pembrolizumab, administered as third line, made possible surgical resection, achieving even an exceptional pathological complete response.