Publications by authors named "A Michelle English"

Background: Given the continued increases in rates of both Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infection, additional diagnostic assays may be useful in increasing access to testing for these sexually transmitted infections. We evaluated the performance of the NeuMoDx™ CT/NG Assay 2.0 on the NeuMoDx-96 and NeuMoDx-288 Molecular Systems.

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Motor axon regeneration after traumatic nerve injuries is a slow process that adversely influences patient outcomes because muscle reinnervation delays result in irreversible muscle atrophy and suboptimal axon regeneration. This advocates for investigating methods to accelerate motor axon growth. Electrical nerve stimulation and exercise both enhance motor axon regeneration in rodents and patients, but these interventions cannot always be easily implemented.

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Article Synopsis
  • A 3-month-old Cane Corso puppy suffered from severe symptoms, including hindlimb lameness and eventual paralysis, leading to its critical condition at the Purdue Veterinary Hospital.
  • Blood tests revealed significant abnormalities, including high levels of creatine kinase, and the puppy tragically went into cardiac arrest shortly after diagnostics.
  • Necropsy findings showed widespread muscle degeneration and inflammation, along with protozoal cysts confirmed by elevated antibody levels, highlighting disseminated neosporosis as a rare but critical cause of ascending paresis in young dogs.
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Aim: Type-2 Diabetes Mellitus (T2DM) affects millions globally, with escalating rates. It often leads to undiagnosed complications and commonly coexists with other health conditions. This study investigates two types of prevalent comorbidities related to T2DM-the circulatory system (DCM1) and digestive system diseases (DCM2)-using clinical, genomic and proteomic datasets.

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Accurately genotyping structural variant (SV) alleles is crucial to genomics research. We present a novel method (kanpig) for genotyping SVs that leverages variant graphs and k-mer vectors to rapidly generate accurate SV genotypes. We benchmark kanpig against the latest SV benchmarks and show single-sample genotyping concordance of 82.

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