Publications by authors named "A Micheli"
Objectives: The present study aims to assess the prevalence, associated clinical symptoms, longitudinal changes, and imaging correlates of Loss of Insight (LOI), which is still unexplored in syndromes associated with Frontotemporal Lobar Degeneration (FTLD).
Design: Retrospective longitudinal cohort study, from Oct 2009 to Feb 2023.
Setting: Tertiary Frontotemporal Dementia research clinic.
Article Synopsis
- - The study investigates hyperorality, a symptom characterized by increased oral behavior, in patients with frontotemporal lobar degeneration (FTLD) and aims to clarify its clinical and imaging correlates.
- - Among 712 FTLD patients, 29% exhibited hyperorality, which was more prevalent in those with severe dementia, younger age, and positive family dementia history; it was most common in behavioral variant frontotemporal dementia (bvFTD).
- - Hyperorality severity increased over time particularly in bvFTD patients and was linked to greater brain atrophy in specific regions, highlighting the need for better clinical understanding for treatment.
Article Synopsis
- The study investigates the cell types and states in the distal region of the uterine tube, which is linked to high-grade serous carcinoma (HGSC), a serious form of ovarian cancer.
- Researchers found that stem/progenitor cells (Slc1a3+) can differentiate into other cell types and that disruption of certain genes (Trp53 and Rb1) can prevent the transformation of these cells into cancer.
- It was revealed that pre-ciliated cells (specific marker expressions) are particularly vulnerable to becoming cancerous, suggesting they could be important targets for diagnosis and treatment.
The efficient coding approach proposes that neural systems represent as much sensory information as biological constraints allow. It aims at formalizing encoding as a constrained optimal process. A different approach, that aims at formalizing decoding, proposes that neural systems instantiate a generative model of the sensory world.
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