Publications by authors named "A Metaxas"
Despite well-documented dysregulation in central serotonergic signaling in Alzheimer's disease (AD), knowledge about the potential involvement of the serotonin-2B receptor (5-HTR) subtype remains sparse. Here, we assessed the levels of 5-HTRs in brain tissue from APP/PS1 transgenic (TG) mice, AD patients, and adult microglial cells. 5-HTR mRNA was measured by RT-qPCR in ageing TG and wild-type (WT) mice, in samples from the middle frontal gyrus of female, AD and control subjects, and in microglia from the cerebral cortex of WT mice.
View Article and Find Full Text PDFRenewable energy projects, such as wind farms and hydropower dams, can indirectly benefit biodiversity by mitigating climate change. However, we explain why such indirect benefits should not contribute towards the accounting of project-level net biodiversity outcomes and provide guidance on the steps needed to legitimately claim no-net-loss of biodiversity.
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- * Mining for these minerals typically leads to biodiversity loss, prompting the exploration of deep seabed mining as an alternative, despite limited comparative studies on environmental impact between land-based and seabed mining.
- * A new framework called the Environmental Impact Wheel is proposed for assessing mining's ecosystem impacts, incorporating multiple attributes and indicators, with steps to facilitate holistic and targeted environmental comparisons.
Transgenic models of familial Alzheimer's disease (AD) serve as valuable tools for probing the molecular mechanisms associated with amyloid-beta (Aβ)-induced pathology. In this meta-analysis, we sought to evaluate levels of phosphorylated tau (p-tau) and explore potential age-related variations in tau hyperphosphorylation, within mouse models of AD. The PubMed and Scopus databases were searched for studies measuring soluble p-tau in 5xFAD, APP/PSEN1, J20 and APP23 mice.
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