Increased keratinocyte activity and PIEZO1 signaling contribute to paclitaxel-induced mechanical hypersensitivity.

Recent work demonstrates that epidermal keratinocytes are critical for normal touch sensation. However, it is unknown whether keratinocytes contribute to touch-evoked pain and hypersensitivity after tissue injury. Here, we used a mouse model of paclitaxel treatment to determine the extent to which keratinocyte activity contributes to the severe neuropathic pain that accompanies chemotherapy.

Physical exercise impacts bone remodeling around bio-resorbable magnesium implants.

Physical exercise has been shown to induce positive reactions in bone healing but next to nothing is known about how it affects the nanostructure, in particular around implants. In this study, we established this link by using small-angle X-ray scattering tensor tomography (SASTT) to investigate nanostructural parameters in 3D such as mineral particle orientation and thickness. As a model system, rat femoral bone with a bio-resorbable implant (ultra-high purity magnesium) was used.

The timing and spatial distribution of mother-offspring interactions in an obligate hider.

Background: Parental care is indispensable for the survival and development of dependent offspring, often requiring a delicate balance of time and energy allocation towards offspring by parents. Among ungulates employing a hider strategy, deciding when and where to provide care while also maintaining a sufficient distance to not reveal the offspring´s hiding place is likely crucial in determining their fate.

Methods: In this study, we analyzed the timing and spatial distribution of mother-offspring interactions in roe deer females (Capreolus capreolus L.

No Future Growth Enhancement Expected at the Northern Edge for European Beech due to Continued Water Limitation.

With ongoing global warming, increasing water deficits promote physiological stress on forest ecosystems with negative impacts on tree growth, vitality, and survival. How individual tree species will react to increased drought stress is therefore a key research question to address for carbon accounting and the development of climate change mitigation strategies. Recent tree-ring studies have shown that trees at higher latitudes will benefit from warmer temperatures, yet this is likely highly species-dependent and less well-known for more temperate tree species.