Publications by authors named "A Menys"
Article Synopsis
- Apraglutide is a new long-acting GLP-2 analog being tested for short bowel syndrome with intestinal failure (SBS-IF) in a phase 2 study.
- The study involved 9 adult patients receiving weekly injections of apraglutide over 52 weeks, measuring its safety and effects on their nutritional needs and intestinal health.
- Results showed significant improvements, including a 52% decrease in parenteral support needs and enhanced absorption of nutrients, alongside a manageable safety profile with mostly mild adverse events.
Background: Colonic motility in constipation can be assessed non-invasively using MRI.
Objective: To compare MRI with high-resolution colonic manometry (HRCM) for predicting treatment response.
Design: Part 1: 44 healthy volunteers (HVs), 43 patients with irritable bowel syndrome with constipation (IBS-C) and 37 with functional constipation (FC) completed stool diaries and questionnaires and underwent oral macrogol (500-1000 mL) challenge.
Background: People with cystic fibrosis (CF) can experience recurrent chest infections, pancreatic exocrine insufficiency and gastrointestinal symptoms. New cystic fibrosis transmembrane conductance regulator (CFTR) modulator drugs improve lung function but gastrointestinal effects are unclear. We aimed to see if a CFTR modulator (tezacaftor-ivacaftor,TEZ/IVA) improves gastrointestinal outcomes in CF.
View Article and Find Full Text PDFObjectives: Magnetic resonance enterography (MRE) interpretation of Crohn's disease (CD) is subjective and uses 2D analysis. We evaluated the feasibility of volumetric measurement of terminal ileal CD on MRE compared to endoscopy and sMARIA, and the responsiveness of volumetric changes to biologics.
Methods: CD patients with MRE and contemporaneous CD endoscopic index of severity-scored ileocolonoscopy were included.
Background: Lactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti-diarrheal actions of ondansetron.
Methods: A double-blind, randomized, placebo-controlled crossover study of the effect of ondansetron 8 mg in 16 healthy volunteers.