Publications by authors named "A Mendoza-Ticona"
Background: Tuberculosis infection (TBI) and TB disease (TBD) incidence remains poorly described following household contact (HHC) rifampin-/multidrug-resistant TB exposure. We sought to characterize TBI and TBD incidence at 1 year in HHCs and to evaluate TB preventive treatment (TPT) use in high-risk groups.
Methods: We previously conducted a cross-sectional study of HHCs with rifampin-/multidrug-resistant TB in 8 high-burden countries and reassessed TBI (interferon-gamma release assay, HHCs aged ≥5 years) and TBD (HHCs all ages) at 1 year.
Objective: To compare the epidemiology of antimicrobial resistance in bacteria isolated from inpatient and outpatient samples in Ecuador.
Methods: A secondary analysis was done of data on bacteria isolated from inpatient and outpatient samples. Data were taken from the 2018 national antimicrobial resistance surveillance database of the National Reference Center for Antimicrobial Resistance.
Article Synopsis
- Household contact investigations are crucial for identifying children who may have been exposed to rifampin-resistant tuberculosis (TB) and may benefit from preventive therapy.
- In a study of 303 child household contacts (HHCs), 57% tested positive for TB infection, with significant factors including smoking by the index case and the child's age and living situation.
- The findings highlight a high prevalence of TB infection and disease among children exposed to rifampin-resistant TB, indicating a need for improved access to preventive therapy for these vulnerable groups.*