Comparative Mitogenome Analysis of Two Native Apple Snail Species (Ampullariidae, ) from Peruvian Amazon.

Apple snails of the genus Perry, 1810 (Mollusca: Caenogastropoda: Ampullariidae) are native to the Neotropics and exhibit high species diversity, holding cultural and ecological significance as an important protein source in Peru. However, most genetic studies in have focused mostly on invasive species, especially in Southeast Asia, where they are considered important pests. In this study, we assembled and annotated the mitochondrial genomes of two species native to the Peruvian Amazon: Ampuero & Ramírez, 2023 and (Deville & Hupé, 1850).

A phase III, multicenter, randomized study of olvimulogene nanivacirepvec followed by platinum-doublet chemotherapy and bevacizumab compared with platinum-doublet chemotherapy and bevacizumab in women with platinum-resistant/refractory ovarian cancer.

Background: Treatment options for patients with platinum-resistant/refractory ovarian cancers are limited and only marginally effective. The development of novel, more effective therapies addresses a critical unmet medical need. Olvimulogene nanivacirepvec (Olvi-Vec), with its strong immune modulating effect on the tumor microenvironment, may provide re-sensitization to platinum and clinically reverse platinum resistance or refractoriness in platinum-resistant/refractory ovarian cancer.

Clinical Activity of Olvimulogene Nanivacirepvec-Primed Immunochemotherapy in Heavily Pretreated Patients With Platinum-Resistant or Platinum-Refractory Ovarian Cancer: The Nonrandomized Phase 2 VIRO-15 Clinical Trial.

Importance: Patients with platinum-resistant or platinum-refractory ovarian cancer (PRROC) have limited therapeutic options, representing a considerable unmet medical need.

Objective: To assess antitumor activity and safety of intraperitoneal (IP) olvimulogene nanivacirepvec (Olvi-Vec) virotherapy and platinum-based chemotherapy with or without bevacizumab in patients with PRROC.

Design, Setting, And Participants: This open-label, nonrandomized multisite phase 2 VIRO-15 clinical trial enrolled patients with PRROC with disease progression following their last prior line of therapy from September 2016 to September 2019.

Anatomical redescription of Aplysia (Aplysia) nigra and Aplysia (Varria) inca (Mollusca: Heterobranchia) with comments on Aplysia from Peru.

During the past century eight species of sea hares of the genus Aplysia were recorded from Peru. However, there is disagreement about how many of these species are valid and their taxonomy needs to be critically evaluated. Based on detailed morphological examinations, this study presents a redescription of Aplysia nigra d'Orbigny, 1837 and Aplysia inca d'Orbigny, 1837, the most common species of Aplysia along the Peruvian coast.

Crystallization Behavior and Morphology of Biodegradable Poly(ε-caprolactone)/Reduced Graphene Oxide Scaffolds.

Morphology, thermal properties and the non-isothermal melt crystallization kinetics of biodegradable poly(ε-caprolactone) (PCL)/reduced graphene oxide (rGO) scaffolds are studied with differential scanning calorimetry (DSC) at various cooling rates (5, 10, 15 and 20 °C/min). Thermally induced phase separation was used to manufacture the scaffolds (TIPS). The micrographs show a more homogeneous and defined morphology with larger pores and thicker pore walls.