Publications by authors named "A Meirhaeghe"
Background: Although the genetic interplay with the environment has a major impact on obesity development, little is known on whether breastfeeding could modulate the genetic predisposition to obesity.
Objectives: To investigate whether breastfeeding attenuates the effect of an obesity genetic risk score (GRS) on adiposity in European adolescents.
Methods: Totally 751 adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) cross-sectional study were included, divided according to breastfeeding status into never breastfed, 1-3 months and ≥4 months.
Obesity remains a serious public health concern. Historically, restrictive diets were the first line of treatment for obesity and are still frequently followed by subjects with obesity. However, some studies showed that dieting may contribute to long-term weight gain.
View Article and Find Full Text PDFFolate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.
Cancer Epidemiol Biomarkers Prev
September 2024
Background: Prenatal folate supplementation has been consistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity and led to inconclusive results.
Methods: We evaluated whether ∼2,900 single-nucleotide polymorphisms (SNP) within 46 candidate genes involved in the folate metabolism pathway influence the risk of childhood ALL, using genome-wide data from nine case-control studies in the Childhood Cancer and Leukemia International Consortium (n = 9,058 cases including 4,510 children of European ancestry, 3,018 Latinx, and 1,406 Asians, and 92,364 controls).
Objectives: First, this registry-based study aimed to comprehensively analyze patients' medical histories and treatments based on ischemic strokes' etiology. We focused on the management of atrial fibrillation among patients diagnosed with cardioembolic stroke. Then, our objective was to identify prognostic factors associated with 28-day mortality.
View Article and Find Full Text PDFArticle Synopsis
- - Early-life high blood pressure can lead to cardiovascular issues in adults, and this study examines how following a Mediterranean Diet (MedDiet) impacts blood pressure in European adolescents, particularly in relation to genetic risk for hypertension (HTN).
- - The research utilized dietary analysis and statistical models, revealing that better adherence to the MedDiet is linked to lower systolic and diastolic blood pressure levels, with notable differences based on gender and genetic predisposition.
- - This is the first study to explore the interplay between MedDiet adherence and HTN genetic risk in influencing blood pressure among adolescents, indicating that diet can help manage BP levels in a genetically susceptible population.