Publications by authors named "A Meinshausen"
Article Synopsis
- Periprosthetic joint infections (PJI) are a frequent cause for needing orthopedic surgeries, and silver-coated titanium alloy surfaces may help reduce bacterial adhesion.
- This study examines how the thickness of silver coatings affects bacterial attachment, proliferation, and bone growth processes, finding that while bacterial attachment is lower on silver surfaces, proliferation remains unaffected.
- The research indicates that even small amounts of silver can effectively combat bacteria without harming osteoblast function, suggesting that this coating technique could be advantageous for enhancing implant performance and reducing infection risks.
Article Synopsis
- The study aims to improve the diagnosis of culture-negative periprosthetic joint infections (PJI) by testing C9 immunostaining as a new tissue biomarker, addressing the issue of misdiagnosis that leads to unnecessary surgeries.
- It involved 98 patients, where standard microbiological methods and serum tests were used, showing increased C-reactive protein (CRP) in PJI cases and significant C9 staining in infected tissue compared to non-infected.
- The C9 biomarker demonstrated a high sensitivity (89%) and good specificity (75%) for detecting PJI, although there were concerns about cross-reactivity with other inflammatory conditions like rheumatoid arthritis.
Aims: Joint infections cause premature implant failure. The avoidance of bacterial colonization of implant materials by modification of the material surface is therefore the focus of current research. In this in vitro study the complex interaction of periodic structures on PET and titanium surfaces on the adhesion of Staphylococcus aureus is analysed.
View Article and Find Full Text PDFBackground: The early diagnosis of suspected periprosthetic low-grade infections in shoulder arthroplasties is important for the outcome of the revision surgical procedures. The aim of this study was to investigate new biomarkers of infection in revision shoulder arthroplasties, taking into account the implant design, patient age, and comorbidities.
Methods: The study included 33 patients with shoulder arthroplasties undergoing revision surgical procedures.
Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure gangliosides in sera reported by other groups the authors analyzed the composition of the extracted LSA by immunochemical approaches.
View Article and Find Full Text PDF