Publications by authors named "A Medina-Sanson"
Background: The few epidemiologic studies of infection exposure in early life and acute leukemia (AL) risk in Latino children have yielded inconsistent results, suggesting a possible effect of ethnicity. Here, we examined the correlation between infection exposure and acute leukemia risk in children from Mexico City-One of the biggest Latino cities worldwide.
Methods: This study included 1455 Mexican children diagnosed with de novo AL (2002-2016), and 1455 control individuals frequency-matched by age and health institution.
Natural killer (NK) cells play a crucial role in innate immunity, particularly in combating infections and tumors. However, in hematological cancers, NK cells often exhibit impaired functions. Therefore, it is very important to activate its endosomal Toll-like receptors (TLRs) as a potential strategy to restore its antitumor activity.
View Article and Find Full Text PDFEpidemiology of childhood acute leukemias in marginalized populations of the central-south region of Mexico: results from a population-based registry.
Front Oncol
February 2024
Article Synopsis
- Acute leukemias (AL) are a leading cause of cancer-related deaths in children under 20 in Mexico, particularly noted in the central-south region, which has been previously understudied compared to Greater Mexico City.
- A population-based study conducted from 2021-2022 identified 388 new cases of AL among children in Puebla, Tlaxcala, and Oaxaca, calculating various incidence rates using demographic data.
- The overall age-standardized incidence rate was around 51.5 cases per million children, with B-cell acute lymphoblastic leukemia being the most prevalent subtype, revealing trends and differences in leukemia incidence among the states.
Evidence of spatial clustering of childhood acute lymphoblastic leukemia cases in Greater Mexico City: report from the Mexican Inter-Institutional Group for the identification of the causes of childhood leukemia.
Front Oncol
February 2024
Background: A heterogeneous geographic distribution of childhood acute lymphoblastic leukemia (ALL) cases has been described, possibly, related to the presence of different environmental factors. The aim of the present study was to explore the geographical distribution of childhood ALL cases in Greater Mexico City (GMC).
Methods: A population-based case-control study was conducted.
Article Synopsis
- Epidemiological studies on acute leukemia (AL) risk factors in infants are limited, but maternal diet during pregnancy may play a crucial role in influencing the occurrence of AL in offspring.
- A case-control study conducted in Mexico City from 2010 to 2019 analyzed maternal dietary habits in 109 infants with AL compared to 252 matched controls, using food frequency questionnaires.
- Results indicated that higher consumption of allium vegetables was linked to a reduced risk of AL, while high-fat dairy products were associated with an increased risk, highlighting the potential impact of maternal nutrition on infant health.