Randomized controlled trial of cognitive behavioral therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injury.

Objective: Evaluate efficacy of cognitive behavioural therapy for sleep and fatigue adapted for brain injury relative to health education control in alleviating sleep disturbance and fatigue after acquired brain injury.

Design: Parallel groups randomized controlled trial.

Subjects: 126 community dwelling adults with stroke or traumatic brain injury.

Methyl 2-[()-5-methyl-2-oxoindolin-3-yl-idene]hydrazinecarbodi-thio-ate.

The title di-thio-carbazate imine, CHNOS, was obtained from the condensation reaction of -methyl-dithio-carbazate (SMDTC) and 5-methyl-isatin. It shows a configuration about the imine C=N bond, which is associated with an intra-molecular N-H⋯O hydrogen bond that closes an (6) ring. In the crystal, inversion dimers linked by pairwise N-H⋯O hydrogen bonds generate (8) loops.

Incidence and Risk Factors for Hypertension among Children with Nephrotic Syndrome.

Objectives: To determine incidence and risk factors for hypertension in childhood nephrotic syndrome.

Study Design: Using data from the Insight into Nephrotic Syndrome (INSIGHT) study, a prospective observational childhood nephrotic syndrome cohort from Toronto, Canada, we evaluated hypertension incidence and time-to-hypertension overall and stratified by 1) steroid-resistance or steroid-sensitivity, and 2) frequently-relapsing, steroid dependent, or infrequently-relapsing. Hypertension was defined as stage 1-2 hypertensive blood pressure on two consecutive visits or anti-hypertensive medication initiation.

Germanyl triazoles as a platform for CuAAC diversification and chemoselective orthogonal cross-coupling.

We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex molecules. The installation of the Ge moiety enables further diversification of the triazole products, including chemoselective transition metal-catalysed cross-coupling reactions using bifunctional boryl/germyl species.

Ethyl (2,3,4)-1-ethyl-2-(furan-2-yl)-4-hy-droxy-5-oxopyrrolidine-3-carboxyl-ate.

The title racemic oxopyrrolidine compound, CHNO, contains three stereogenic centres and crystallizes with two mol-ecules in the asymmetric unit. The five-membered pyrrolidine rings in both mol-ecules exhibit envelope conformations. The -ethyl group of one of the mol-ecules is disordered over two sets of sites in a 0.