Publications by authors named "A McKINNON"
Study Objectives: While alterations in rest-activity rhythms are common in older adults 'at risk' for dementia, it is unclear how rest-activity rhythms relate to underlying brain integrity.
Methods: Older adults aged > 50 years (n=143, mean age=67) with subjective and/or objective cognitive impairment underwent MRI scanning and 14-days of actigraphy. The following non-parametric measures were computed: intra-daily variability (IV), inter-daily stability (IS), relative amplitude (RA), and average activity during the least active 5-hour period (L5).
Human immunodeficiency virus (HIV) infection has a plethora of effects on its host, including increased susceptibility to opportunistic infections and increased likelihood of developing HIV-associated malignancies. The combined cellular dysfunction orchestrated by co-infection with oncogenic viruses, such as human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV), further amplifies the risk of malignancy in people living with HIV/AIDS (PLHA). We report a rare case of Kaposi sarcoma (KS) and extra cavitary primary effusion lymphoma (EPEL) in a 48-year-old woman with advanced HIV disease on antiretroviral treatment presenting with arthralgia, generalized body weakness, drenching night sweats, cavitary effusions, a violaceous rash on her left leg, as well as generalized lymphadenopathy.
View Article and Find Full Text PDFObjectives: To review publicly available physical activity (PA) resources for individuals with rheumatoid arthritis (RA). Aims were to find online print and audiovisual resources, review their characteristics and critically examine their quality from medical, exercise and behavioural science perspectives.
Design: An environmental scan was completed using the Google search engine, following a pragmatic approach to reviewing patient-facing self-care resources.
Background: Cognitive therapy for PTSD (CT-PTSD) is an efficacious treatment for children and adolescents with post-traumatic stress disorder (PTSD) following single incident trauma, but there is a lack of evidence relating to this approach for youth with PTSD following exposure to multiple traumatic experiences.
Aims: To assess the safety, acceptability and feasibility of CT-PTSD for youth following multiple trauma, and obtain a preliminary estimate of its pre-post effect size.
Method: Nine children and adolescents (aged 8-17 years) with multiple-trauma PTSD were recruited to a case series of CT-PTSD.
Background: The identification of predictors of treatment response is crucial for improving treatment outcome for children with anxiety disorders. Machine learning methods provide opportunities to identify combinations of factors that contribute to risk prediction models.
Methods: A machine learning approach was applied to predict anxiety disorder remission in a large sample of 2114 anxious youth (5-18 years).