Publications by authors named "A McDonough"
The NCCN Guidelines for Survivorship include recommendations for screening, evaluation, and treatment of psychosocial and physical problems resulting from adult-onset cancer and its treatment. They also include recommendations to promote healthy behaviors and immunizations in survivors and provide a framework for care coordination. These NCCN Guidelines Insights summarize the panel's current recommendations regarding sexual health and fertility.
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- The study investigates the effects of repeated administration of three types of pharmaceutical-grade medium chain triglycerides (MCTs) in mice, focusing on their tolerability via oral and intraperitoneal routes.
- Results showed significant toxicity and 100% mortality in mice receiving a higher dose of MCTs intraperitoneally, while those receiving the same dose orally did not experience adverse effects.
- The findings highlight the importance of dose and route of administration in evaluating the safety of MCTs, indicating a need for careful consideration in pharmacological studies.
Vascular injury and pathologies underlie common diseases including ischemic stroke and cerebral small vessel disease (CSVD). Prior work has identified a key role for glial cells, including microglia, in the multifaceted and temporally evolving neuroimmune response to both stroke and CSVD. Transcriptional profiling has led to important advances including identification of distinct gene expression signatures in ischemia-exposed, flow cytometrically sorted microglia and more recently single cell RNA sequencing-identified microglial subpopulations or clusters.
View Article and Find Full Text PDFMaintaining extracellular potassium (K) within narrow limits, critical for membrane potential and excitability, is accomplished through the internal redistribution of K between extracellular fluid (ECF) and intracellular fluid (ICF) in concert with the regulation of renal K output to balance K intake. Here we present evidence from high-precision analyses of stable K isotopes in rats maintained on a control diet that the tissues and organs involved in the internal redistribution of K differ in their speed of K exchange with ECF and can be grouped into those that exchange K with ECF either rapidly or more slowly ("fast" and "slow" pools). After 10 days of K restriction, a compartmental analysis indicates that the sizes of the ICF K pools decreased but that this decrease in ICF K pools was not homogeneous, rather occurring only in the slow pool (15% decrease, < 0.
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- - The guidance for clinicians diagnosing cauda equina syndrome in England has improved, but lacks specific advice for patients with recent imaging showing no compression who return with new symptoms.
- - This study analyzed case notes of 45 patients who sought care at an Emergency Department for cauda equina syndrome and underwent MRI, focusing on changes in symptoms from their first to subsequent visits.
- - Results indicated that patients reporting an increase in symptoms were more likely to show cauda equina compression on their second MRI, suggesting that further imaging may be warranted even if previous scans were reassuring.