Improving STEMI Management Internationally: Initial Report of the American College of Cardiology-Global Heart Attack Treatment Initiative.

Background: The burden of ST-segment elevation myocardial infarction (STEMI) worldwide is increasing as the leading cause of death; there are scant data on system-based initiatives and performance metrics relative to its management in low- and middle-income countries where resources are frequently limited.

Objectives: The Global Heart Attack Treatment Initiative (GHATI) ultimate aim is improving evidence-based STEMI care, adherence to guidelines, and tracking of clinical and institutional indicators in low- and middle-income countries. To achieve that goal, the process of care and outcomes of STEMI patients in those nations will be studied.

An institution-wide mixed methods assessment of healthcare transition.

Background: Healthcare transition (HCT) is the process of moving a patient from pediatric, parent-supervised care to an independent, adult-centered model. This study assesses current HCT activities and explores the educational and system-based needs for effective HCT processes in a single institution.

Methods: We interviewed division/care program leaders at one academic tertiary-care children's hospital regarding HCT practices.

From algae to plants: understanding pyrenoid-based CO-concentrating mechanisms.

Pyrenoids are the key component of one of the most abundant biological CO concentration mechanisms found in nature. Pyrenoid-based CO-concentrating mechanisms (pCCMs) are estimated to account for one third of global photosynthetic CO capture. Our molecular understanding of how pyrenoids work is based largely on work in the green algae Chlamydomonas reinhardtii.