Publications by authors named "A Mazumdar"
The biosynthesis of the lincosamide antibiotics lincomycin A and celesticetin involves the pyridoxal-5'-phosphate (PLP)-dependent enzymes LmbF and CcbF, which are responsible for bifurcation of the biosynthetic pathways. Despite recognizing the same S-glycosyl-L-cysteine structure of the substrates, LmbF catalyses thiol formation through β-elimination, whereas CcbF produces S-acetaldehyde through decarboxylation-coupled oxidative deamination. The structural basis for the diversification mechanism remains largely unexplored.
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- Classical systems allow measurements without causing disturbance, while quantum systems do not, particularly in the context of gravity.
- The proposed experimental setup involves multiple interferometers to measure a gravitational field created by a spatial superposition, aiming to demonstrate nonclassical effects.
- This test is unique as it doesn't rely on specific nonclassical gravity forms or entanglement, and it can detect quantum measurement disturbance regardless of decoherence rates, making it device independent.
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- Culicoides oxystoma is a significant vector for various diseases affecting livestock and wildlife in tropical and subtropical regions, necessitating a deeper understanding of its associated bacterial communities.
- The study cataloged the bacteria present at different life stages of C. oxystoma, comparing lab-reared specimens with those collected from the field, using techniques like Sanger sequencing of 16S rRNA to identify dominant bacterial phyla.
- Key findings revealed that Firmicutes and Proteobacteria, particularly Bacillus species, were prevalent in multiple life stages, indicating their potential role in influencing the vector's capacity, digestion, and larval development and highlighting areas for future research.
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- * All surgical methods significantly reduced intraocular pressure (IOP), with trabeculectomy showing the highest vision improvement and complete success rates, but also a higher complication rate compared to the other methods.
- * The findings highlight that while all three procedures effectively manage IOP, trabeculectomy may be preferred for better visual outcomes, though it comes with increased risks, indicating the need for tailored treatment plans.
Purpose: Rexinoids, agonists of nuclear retinoid X receptor (RXR), have been used for the treatment of cancers and are well tolerated in both animals and humans. However, the usefulness of rexinoids in treatment of breast cancer remains unknown. This study examines the efficacy of IRX4204, a highly specific rexinoid, in breast cancer cell lines and preclinical models to identify a biomarker for response and potential mechanism of action.
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