Publications by authors named "A Mauer"
Intrahepatic macrophages in nonalcoholic steatohepatitis (NASH) are heterogenous and include proinflammatory recruited monocyte-derived macrophages. The receptor for advanced glycation endproducts (RAGE) is expressed on macrophages and can be activated by damage associated molecular patterns (DAMPs) upregulated in NASH, yet the role of macrophage-specific RAGE signaling in NASH is unclear. Therefore, we hypothesized that RAGE-expressing macrophages are proinflammatory and mediate liver inflammation in NASH.
View Article and Find Full Text PDFWe present design and performance data of an energy-scaled diode-pumped Alexandrite laser in single longitudinal mode operation developed as a beam source in a mobile general-purpose Doppler lidar. A maximum pulse energy in Q-switched operation of 4.6 mJ and a maximum average power of 2.
View Article and Find Full Text PDFArticle Synopsis
- - Sphingosine 1-phosphate (S1P) is linked to nonalcoholic steatohepatitis (NASH), where immune cell inflammation plays a crucial role in the disease's progression.
- - A murine study indicated that using specific S1P receptor modulators, like Etrasimod, improved liver injury and inflammation by altering intrahepatic leukocyte populations, leading to a decrease in T cells and B cells and an increase in myeloid and other immune cells.
- - Unlike Etrasimod, the other modulator Amiselimod did not produce significant changes in leukocyte frequencies or improve liver conditions in mice fed a high-fat diet, suggesting varied effects of different S
Objective: Compare characteristics and clinical outcomes of dogs with infectious keratitis from considered to be multidrug-resistant (MDR) or not.
Procedures: isolated as the primary pathogen from canine patients with ulcerative keratitis were considered MDR if resistant to at least one agent in three or more classes of antibiotics. Medical records were reviewed for history, patients' characteristics, clinical appearance, therapeutic interventions, and clinical outcomes.
Background: Little is known about the characteristics of oncological patients, cancer therapy-induced cardiotoxicity, and guidelines-directed interventions in the Caribbean; analysis of cardio-oncology services may shed light on this and clarify links between ethnicity, cultural, and local socioeconomic factors.
Objectives: This study compared patients' phenotypes, adherence to guidelines recommendations, and patterns of cardiotoxicity between two cardio-oncology programs: one in the Dominican Republic (DR) and the other in Chicago IL, United States (US).
Methods: Patients being considered for or treated with potentially cardiotoxic drugs were followed before, during, and after chemotherapy through both cardio-oncology clinics, where we recorded and compared clinical, demographic, and echocardiographic data.