Publications by authors named "A Mattiello"
co-evolving with the CAG-repeat tract - modulates Huntington's disease phenotypes.
Mol Ther Nucleic Acids
September 2024
Article Synopsis
- Circular RNA (circRNA) is important for brain development and disorders, especially in Huntington's disease (HD).
- Researchers found a specific circRNA from the HD gene, which is most common in the brain and changes with the size of a DNA repeat in people and mice with HD.
- Although this circRNA doesn’t seem to make proteins in adult mouse brains, it might help regulate protein production and improve some problems caused by HD in brain cells.
Copper (Cu) concentration in agricultural soils often exceeds toxicological limits due to application of Cu-based fungicides. The potential of weeds for their use as functional cover plants in vineyard management and phytoremediation practices is little explored. We identified five weed species widely present in vineyards and assessed their Cu accumulation from eleven Mediterranean vineyards (soil Cu: 60-327 μg g) and two adjacent control sites (soil Cu: 15-30 μg g).
View Article and Find Full Text PDFBackground: Inflammation has been hypothesized to play a role in the development and progression of breast cancer and might differently impact breast cancer risk among pre and postmenopausal women. We performed a nested case-control study to examine whether pre-diagnostic circulating concentrations of adiponectin, leptin, c-reactive protein (CRP), tumour necrosis factor-α, interferon-γ and 6 interleukins were associated with breast cancer risk, overall and by menopausal status.
Methods: Pre-diagnostic levels of inflammatory biomarkers were measured in plasma from 1558 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
Serum thyrotropin (TSH) receptor antibodies (TRAbs) are occasionally found in patients with amiodarone-induced thyrotoxicosis (AIT), and usually point to a diagnosis of type 1 AIT (AIT1) due to Graves' disease (GD). However, the TRAb role and function in AIT have not been clarified. A retrospective cohort study of 309 AIT patients followed at a single academic center over a 30-year period.
View Article and Find Full Text PDFBackground: Endometrial cancer is strongly associated with obesity and dysregulation of metabolic factors such as estrogen and insulin signaling are causal risk factors for this malignancy. To identify additional novel metabolic pathways associated with endometrial cancer we performed metabolomic analyses on pre-diagnostic plasma samples from 853 case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC).
Methods: A total of 129 metabolites (acylcarnitines, amino acids, biogenic amines, glycerophospholipids, hexoses, and sphingolipids) were measured by liquid chromatography-mass spectrometry.