Publications by authors named "A Matsushita"
Article Synopsis
- Collaborative surgery involving both endoscopists and surgeons is shown to be an effective method for less invasive removal of gastrointestinal tumors, addressing the limitations of traditional treatments.
- In a study of 131 patients with various lesions, 96% achieved complete collaboration, and 95% had successful tumor resections.
- Overall, the results suggest that this collaborative approach is safe, with only 4% experiencing significant postoperative issues, making it a viable alternative to conventional surgical methods.
Status epilepticus (SE)-induced Takotsubo cardiomyopathy (TTC) frequently manifests as a hemodynamic compromise, including shock, despite heart failure therapy. This can result in life-threatening events that pose significant diagnostic challenges. We report the case of a 57-year-old woman who was successfully diagnosed with TTC, without hemodynamic compromise, and treated.
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- * A study involving six sessions of gait training with a hybrid assistive limb (HAL) over 4.5 years showed improvements in walking distance and knee strength, while maintaining mobility and daily living activities for a male patient.
- * The findings suggest that intermittent gait training could be a beneficial rehabilitation strategy for patients with myotonic dystrophy type 1, although the frequency and number of training sessions require further exploration for optimal effectiveness.
Article Synopsis
- The study focuses on the four key driver genes (KRAS, CDKN2A, TP53, SMAD4) in pancreatic ductal adenocarcinoma (PDAC), with KRAS and TP53 being the most common mutations.
- Researchers developed organoids with KRAS mutations and TP53 loss of function to analyze how these mutations affect cellular processes, specifically highlighting enhanced glycolysis in the double-mutant organoids.
- They identified triosephosphate isomerase (TPI1) as a potential therapeutic target, as its loss decreased cell proliferation in PDAC cells with TP53 mutations, present in about 70% of PDAC patients.
Article Synopsis
- A 31-year-old pregnant woman at 37 weeks experienced right upper quadrant pain and was diagnosed with acute cholangitis caused by a type-Ia choledochal cyst.
- After conservative treatment improved her condition, she delivered her baby via C-section at 38 weeks.
- The mother underwent laparoscopic surgery to remove the cyst and reconstruct the bile duct 47 days postpartum, recovering well with normal liver function 7 years later.