Electrophysiologic effects of flecainide relative to serum and tissue concentrations in rabbits after chronic drug administration.

The effects of chronic treatment with flecainide on the cellular electrophysiology and the relationship of the electrophysiologic effects to serum and myocardial flecainide concentrations were determined in rabbit ventricular myocardium. Two groups of rabbits were administered flecainide at doses of 7.5 mg/kg body weight (dose I) and 20 mg/kg body weight (dose II) intraperitoneally (i.

Dose-dependent tissue uptake of flecainide during chronic administration in rabbits.

This study was designed to examine the metabolism of flecainide after repeated administration to rabbits. New Zealand White rabbits were administered either 7.5 mg/kg body weight (dose I) or 20 mg/kg body weight (dose II) flecainide twice daily intraperitoneally for 12-14 days.