Publications by authors named "A Mastrofrancesco"
Wound repair and skin regeneration is a very complex orchestrated process that is generally composed of four phases: hemostasis, inflammation, proliferation, and remodeling. Each phase involves the activation of different cells and the production of various cytokines, chemokines, and other inflammatory mediators affecting the immune response. The microbial skin composition plays an important role in wound healing.
View Article and Find Full Text PDFGlucocorticoids (GCs) are commonly used in the treatment of inflammatory skin diseases, although the balance between therapeutic benefits and side effects is still crucial in clinical practice. One of the major and well-known adverse effects of topical GCs is cutaneous atrophy, which seems to be related to the activation of the glucorticoid receptor (GR) genomic pathway. Dissociating anti-inflammatory activity from atrophogenicity represents an important goal to achieve, in order to avoid side effects on keratinocytes and fibroblasts, known target cells of GC action.
View Article and Find Full Text PDFCutaneous squamous cell carcinoma (cSCC) is the most common UV-induced keratinocyte-derived cancer, and its progression is characterized by the epithelial-mesenchymal transition (EMT) process. We previously demonstrated that PPARγ activation by 2,4,6-octatrienoic acid (Octa) prevents cutaneous UV damage. We investigated the possible role of the PPARγ activators Octa and the new compound (2Z,4E,6E)-2-methoxyocta-2,4,6-trienoic acid (A02) in targeting keratinocyte-derived skin cancer.
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- Sebum, a lipid mixture produced by sebaceous glands, plays a role in skin health by influencing epidermal and dermal cell regulation, especially in acne-prone skin through various fatty acids and inflammatory processes.
- Saturated fatty acids (SFAs) like palmitate (C16:0), margarate (C17:0), and stearate (C18:0) contribute differently to inflammation in sebocytes, with palmitate showing the most significant effects due to its ability to undergo extensive desaturation.
- Experiments indicated that inhibiting the enzymes responsible for fatty acid desaturation can actually worsen the inflammation response in sebocytes, highlighting the complex interactions between fatty acids and inflammatory cytokine production.
Methicillin-resistant Staphylococcus aureus (MRSA) has become the leading cause of skin and soft tissue infections (SSTIs). Biofilm production further complicates patient treatment, contributing to increased bacterial persistence and antibiotic tolerance. The study aimed to explore the efficacy of different antibiotics on biofilm-producing MRSA isolated from patients with SSTI.
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