Publications by authors named "A Marzullo"
Chromosomal abnormalities (CAs) are changes in the number or structure of chromosomes, manifested as alterations in the total number of chromosomes or as structural abnormalities involving the loss, duplication, or rearrangement of chromosomal segments. CAs can be inherited or can occur spontaneously, leading to congenital malformations and genetic diseases. CAs associated with cardiovascular diseases cause structural or functional alterations of the heart, affecting the cardiac chambers, valves, coronary arteries, aorta, and cardiac conduction, thus increasing the likelihood of arrhythmias, cardiac arrest, and sudden cardiac death (SCD).
View Article and Find Full Text PDFBackground: Autopsy is a medical procedure that consists of the examination of the corpse to determine the cause of death and obtain information on pathological conditions or injuries. In recent years, there has been a reduction in hospital autopsies and an increase in forensic autopsies.
Aim: To evaluate the utility of autopsy in the modern age and the discrepancy between clinical and autopsy diagnoses.
Hereditary aortopathies are a group of rare genetic diseases affecting the aorta and its major branches, and they represent a cause of sudden cardiac death. These pathologies are classified into syndromic hereditary aortopathies and non-syndromic hereditary aortopathies. The epidemiology of hereditary aortopathies varies according to the specific genetic condition involved; however, these disorders are believed to account for a significant proportion of sudden cardiac death in young individuals with a family history of inherited cardiovascular conditions.
View Article and Find Full Text PDFArticle Synopsis
- The distinction between viable and post-mortem lesions in forensic medicine is crucial, particularly in advanced decomposition cases.
- Glycophorin A (GPA) is a key immunohistochemical marker that can identify lesion viability for up to six months, though its effectiveness diminishes after 15 days.
- Other markers like tryptase, IL-15, and CD15 have been explored, but their results regarding decomposition remain unclear, leading to a review of their use in forensic investigations.
Cardiac Amyloidosis: State-of-the-Art Review in Molecular Pathology.
Curr Issues Mol Biol
October 2024
Article Synopsis
- - Amyloidosis is a group of diseases caused by misfolded proteins that form harmful deposits in tissues, potentially affecting various organs, with amyloid fibrils being particularly resistant to breakdown.
- - The condition can result from factors like aging or genetic variations, harming organ function through disruptions in tissue structure and direct toxicity, which often leads to serious issues such as heart failure.
- - Diagnosing cardiac amyloidosis is challenging and usually involves tissue biopsies and special staining methods, while the review highlights key forms of the disease, their treatment, and the need for a collaborative approach to care.