RANKL regulates differentially breast cancer stem cell properties through its RANK and LGR4 receptors.

Background: Breast cancer stem cells (BCSC) are a subpopulation responsible for cancer resistance and relapse. The receptor activator of nuclear factor kappa-Β ligand (RANKL) is a cytokine capable of activating RANK and LGR4 receptors. RANKL/RANK signaling maintains the self-renewal of BCSCs, however, the effect of RANKL via LGR4 remains unclear.

Impact of climate change on the distribution of insectivorous bats: Implications for small-scale farming in southern Mexico.

Bats provide important ecosystem services for agriculture, such as pest control, a function that is particularly relevant for small-scale farmers. However, climate change is causing a decrease in bat populations. To assess the potential impacts of climate change on insectivorous bats and the implications on small-scale farming of indigenous communities in the Chiapas Highlands in southern Mexico we developed a three-step protocol: (1) projecting distribution shifts of insectivorous bats under climate change scenarios using non-dispersal and limited-full dispersal assumptions, (2) using official information to estimate the average economic value of conducting chemical pest control in crops at a state level, (3) surveying small-scale farmers to estimate the local economic value of pest control and determine how bats are perceived by small-scale farmers.

Administration of Tamoxifen Can Regulate Changes in Gene Expression during the Acute Phase of Traumatic Spinal Cord Injury.

Traumatic spinal cord injury (SCI) causes irreversible damage leading to incapacity. Molecular mechanisms underlying SCI damage are not fully understood, preventing the development of novel therapies. Tamoxifen (TMX) has emerged as a promising therapy.

Contesting views on mobility restrictions in urban green spaces amid COVID-19-Insights from Twitter in Latin America and Spain.

Positive sentiments towards urban green spaces (UGS) unequivocally increased worldwide amid COVID-19. In contrast, this paper documents that views on mobility restrictions applicable to UGS are of a contested nature. That is, while residents unambiguously report positive sentiments towards UGS, they do not share views on how to administer access to UGS-which is a matter of public policy.

Adaptive governance of urban green spaces across Latin America - Insights amid COVID-19.

Urban green spaces' well documented role as a hub for physical and mental health was enhanced by restrictions to mobility issued worldwide as a response to COVID-19. In this context, managers of urban green spaces (UGS) were prompted to provide controlled access under safety protocols. This unprecedented challenge required planning and operational strengths reflecting flexibility, innovation and learning.