Publications by authors named "A Martinez-Aran"
Background: Studies have shown associations between polygenic risk scores for educational attainment (PRS), cognitive reserve (CR), cognition, negative symptoms (NS), and psychosocial functioning in first-episode psychosis (FEP). However, their specific interactions remain unclear. This study aimed to investigate the mediating roles of CR, cognition, and NS in the relationship between PRS and psychosocial functioning one year after a FEP.
View Article and Find Full Text PDFOlder Adults with Bipolar Disorder (OABD) represent a heterogeneous group, including those with early and late onset of the disorder. Recent evidence shows both groups have distinct clinical, cognitive, and medical features, tied to different neurobiological profiles. This study explored the link between polygenic risk scores (PRS) for bipolar disorder (PRS-BD), schizophrenia (PRS-SCZ), and major depressive disorder (PRS-MDD) with age of onset in OABD.
View Article and Find Full Text PDFArticle Synopsis
- This study investigated sex differences in patients experiencing their first episode of mania (FEM) or psychosis (FEP) to develop targeted treatment approaches.
- A total of 113 patients were assessed across various clinical and neuropsychological domains, revealing that women generally outperformed men in verbal memory and emotional intelligence, while men excelled in working memory.
- Findings suggest significant interactions between sex and conditions, indicating a need for treatment strategies that consider these differences in cognitive performance and emotional capabilities.
Background: Functional recovery remains a core clinical objective for patients with bipolar disorder (BD). Sociodemographic, clinical, and neurocognitive variables are associated with long-term functional impairment, yet the impact of sex differences is unclear. Functional remediation (FR) is a validated intervention aimed at achieving functional recovery in BD.
View Article and Find Full Text PDFAim: To analyze the clinical, neurocognitive, and functional impact of prolactin levels according to sex in patients with a First Episode Psychosis (FEP).
Methods: We measured prolactin levels in 221 non-affective FEP patients treated with antipsychotics (AP) and 224 healthy controls, at baseline and 2-year follow-up. We examined whether the relationships between clinical and functional variables were mediated by prolactin, controlling for antipsychotic use, according to sex.