Menstrual Disorders in Adolescence: Diagnostic and Therapeutic Challenges.

: Adolescence is the period of life between the ages of 10 and 19. This period is essentially dominated by puberty. The first menstruation, called menarche, occurs, on average, at the age of 12-13.

Contemporary Survival Selection Fails to Explain Observed Patterns of Phenotypic Divergence Between Suburban and Forest Populations of the Cuban Endemic Lizard, .

Although urbanization is a major threat to biodiversity, some native species have managed to persist in urban areas. Populations of such species often show phenotypic differences with their rural counterparts. A crucial question is whether such differences result from different selection regimes between habitats.

Cardiac findings in a phase II double-blind randomized placebo-controlled trial of combination therapy (HAZDPac) to treat COVID-19 patients.

Objective: Hydroxychloroquine paired with Azithromycin, Vitamin C, Vitamin D, and Zinc (HAZDPac), was used as a multidrug therapy method to treat COVID-19 illness and superimposed secondary bacterial pneumonia. Concerns have been raised though about such combinations regarding cardiac QTc interval prolongation and risks of arrhythmias, which we set out to address in this study.

Design: We evaluated cardiac safety in a Phase II Double-Blind Randomized Placebo-Controlled Trial of Combination Therapy to Treat COVID-19 Infections study, conducted by ProgenaBiome.

Multi-resolution X-ray micro-computed tomography images of carbonate rocks from brazilian pre-salt.

The recent surge in artificial intelligence (AI) advancements has been driven by the availability of open datasets for model development and evaluation. However, in the field of earth sciences, particularly in digital rock physics applications, open data remains scarce. To bridge this gap, we introduce a dataset comprising 16 rock samples from the Brazilian pre-salt region, available in both low resolution (48 μm - 64 μm) and high resolution (6 μm - 8 μm).

Long-Term Effects on Gonadal Function After Treatment of Colorectal Cancer: A Systematic Review and Meta-Analysis.

Background: The incidence of colorectal cancer (CRC) is increasing in the population under 50 years of age, with more than 10% of cases occurring in young adults. Fertility preservation counseling has therefore received increased attention in this younger patient population. The treatment of CRC is often based on multimodal therapies, including surgery, radiotherapy, chemotherapy, and, more recently, immunotherapy, which makes it difficult to estimate the expected effect of treatment on fertility.