Publications by authors named "A Martinez Isla"
Calcium pyrophosphate disease (CPPD) is a commonly diagnosed crystal-induced disease that typically presents as acute monoarticular or oligoarticular arthritis. It is less commonly seen in the spine, and its clinical importance in this area is still relatively understudied. Isolated spinal CPPD is quite rare; a diagnosis of spinal CPPD is almost always accompanied by peripheral CPPD.
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- Piscirickettsiosis, caused by the pathogen P. salmonis, significantly impacts the Chilean aquaculture industry, leading to major economic losses, and traditional genotyping methods are limited in cost and expertise requirements.
- This study introduces Loop-mediated Isothermal Amplification (LAMP) as a faster, cheaper, and simpler alternative for diagnosing P. salmonis, developing specific assays for both species identification and differentiation between its genogroups LF-89 and EM-90.
- LAMP assays showed sensitivity and specificity on par with traditional methods while being more suitable for field use, indicating potential for improved disease management and surveillance in salmonid aquaculture.
Peripheral nerve and large-scale muscle injuries result in significant disability, necessitating the development of biomaterials that can restore functional deficits by promoting tissue regrowth in an electroactive environment. Among these materials, graphene is favored for its high conductivity, but its low bioactivity requires enhancement through biomimetic components. In this study, we extrusion printed graphene-poly(lactide-co-glycolide) (graphene) lattice scaffolds, aiming to increase bioactivity by incorporating decellularized extracellular matrix (dECM) derived from mouse pup skeletal muscle.
View Article and Find Full Text PDFPopulation pharmacokinetics of oral fosfomycin calcium in healthy women.
J Antimicrob Chemother
November 2024
Article Synopsis
- Fosfomycin is an antibiotic commonly used for treating uncomplicated urinary tract infections in women, and further studies are recommended to understand its pharmacokinetics better.
- A clinical trial involved 24 healthy women who received different doses of oral fosfomycin calcium, and plasma samples were collected to model its pharmacokinetics.
- The results indicated that fosfomycin's pharmacokinetics fit a two-compartment model, revealing that factors like creatinine clearance and body weight influence its clearance and distribution, aiding in dosage recommendations for treating urinary tract infections.
Article Synopsis
- Additional monitoring medicines often have limited safety information due to rare adverse drug reactions not being detected in clinical trials, highlighting the need for real-world studies.
- A study involving community pharmacists aimed to enhance safety, treatment adherence, and patient knowledge about these medicines in chronic disease patients, showing promising results over a six-month period.
- Significant reductions in adverse drug reactions and patient non-adherence were achieved, alongside improved understanding of medicines and enhanced quality of life for patients.