Publications by authors named "A Martinez Aparicio"
Article Synopsis
- The Vitamin D Antenatal Asthma Reduction Trial (VDAART) studied children from 6 months to 8 years and found links between specific gene variants and children's body mass index.
- These associations also connected microbiome characteristics tied to obesity with important lipids and amino acids.
- The findings suggest that genetic factors play a role in influencing the microbiome during development and highlight potential biomarkers for childhood obesity and related health issues like insulin resistance and type 2 diabetes.
The lack of accurate, cost-effective, and clinically relevant biomarkers remains a major barrier to incorporating omic data into clinical practice. Previous studies have shown that DNA methylation algorithms have utility as surrogate measures for selected proteins and metabolites. We expand upon this work by creating DNAm surrogates, termed epigenetic biomarker proxies (EBPs), across clinical laboratories, the metabolome, and the proteome.
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- - The study investigates the early interactions between infants with Down syndrome and their caregivers, contrasting them with typically developing infants, and highlights that these interactions significantly impact long-term cognitive, emotional, and social development.
- - A total of 128 dyads (64 with Down syndrome and 64 typically developing) participated, with assessments revealing notable differences in parental sensitivity and engagement during interactions, particularly influenced by the child's gender.
- - Findings indicate that caregivers of children with Down syndrome tend to be less sensitive and more directive, while these children demonstrate lower attention to caregivers, although girls with Down syndrome received more sensitive care and displayed varying negative emotions compared to boys.