Publications by authors named "A Martinez"

Novel lipophilic hydroxytyrosol N-alkylcarbamate conjugates were synthesized by coupling several alkyl isocyanates of different chain lengths with the primary hydroxy group of this natural phenol. These N-alkylcarbamate conjugates were tested as antitrypanosomal and antileishmanial agents, and their cytotoxicity was evaluated against the human MRC-5 and THP-1 cell lines. Five of these N-alkylcarbamate derivatives showed submicromolar IC concentrations against Trypanosoma brucei brucei, with values ranging from 0.

View Article and Find Full Text PDF

Occupational ApplicationsOur study evaluated four occupational exoskeletons using universal design principles, and we found that the exoskeleton design needs improvement to achieve equitable use by diverse worker sets (including disabled, older, and women workers). Assembling exoskeletons for use, donning and doffing wearable devices, and disassembling them can all be difficult because of the strength, dexterity, reach, and balance requirements of users. Workers with disabilities are likely to require additional support from another person to assemble or use these devices.

View Article and Find Full Text PDF

The accelerating growth of make-on-demand chemical libraries provides unprecedented opportunities to identify starting points for drug discovery with virtual screening. However, these multi-billion-scale libraries are challenging to screen, even for the fastest structure-based docking methods. Here we explore a strategy that combines machine learning and molecular docking to enable rapid virtual screening of databases containing billions of compounds.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionk9vb3kghnijd930vgqk7tuqfpikr42qs): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: controllers/Author.php

Line Number: 219

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 219
Function: _error_handler

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: libraries/Pagination.php

Line Number: 413

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 274
Function: create_links

File: /var/www/html/index.php
Line: 316
Function: require_once