Ovarian steroids modulate mRNA expression of ECM associated genes and collagen deposition induced by TGF β1 in equine endometrium in vitro.

Equine endometrosis is a major cause of infertility in mares and is characterized by degenerative, functional and fibrotic changes in the endometrium with increased collagen (COL) deposition. Transforming growth factor (TGF)-β1 is one of the major pro-fibrotic factors involved in the excessive deposition of extracellular matrix (ECM) components in the equine endometrium. It has been demonstrated that ovarian steroids, specifically 17β-estradiol (E2) and progesterone (P4), not only regulate the cyclicity of the estrous cycle, but also have been implicated as anti- or pro-fibrotic factors.

EGHRIN conclusions on pandemic preparedness: no whole-of-society approach without society.

Pandemic preparedness necessitates a multifaceted approach that emphasizes societal factors, such as building trust and acknowledges cultural and societal differences, with a focus on protecting vulnerable groups. To support these goals, the European Global Health Research Institutes Network has outlined a comprehensive transdisciplinary approach through a set of multilevel recommendations.

Osteopoikilosis-the incidental finding of a rare bone dysplasia: A case report.

Key Clinical Message: Osteopoikilosis is an asymptomatic osteosclerotic dysplasia, of autosomal dominant inheritance, which does not cause deformity or alteration in bone development, of incidental diagnosis. The differential diagnosis should be made with osteoblastic metastases, among others, especially if it is asymmetric and in patients over 50 years of age.

Abstract: Osteopoikilosis is a rare benign bone disease, characterized by the appearance of bone islands in the osseous tissue, which could be confused with bone metastasis.

Prevalence and perceptions of gender-based violence, and factors associated with gender-based violence among adolescents in Addis Ababa, Ethiopia: A Cross-sectional study.

This study examined the prevalence and perception of Gender-Based Violence (GBV) and factors associated with GBV among in-school Ethiopian adolescents. This cross-sectional quantitative study was conducted in Addis Ababa with 1,014 male and female adolescents aged 15-19. We examined differences by sex using the two-sample test of proportions and used multiple regression models to identify factors associated with GBV.

A systematic review and meta-analysis of data on pregnant women with confirmed COVID-19: Clinical presentation, and pregnancy and perinatal outcomes based on COVID-19 severity.

Background: We determined the clinical presentation, risk factors, and pregnancy and perinatal outcomes in pregnant women with confirmed COVID-19 and identified if these are different based on COVID-19 severity.

Methods: We included all observational studies on pregnant women with confirmed COVID-19 reporting clinical presentation, risk factors, and pregnancy and perinatal outcomes. We included all studies published between Dec/2019-Feb/2021 in Medline, Embase, the WHO COVID-19 databases, and clinicaltrials.