Publications by authors named "A Marthe Schreuder"
Fasting hypoglycemia is a severe and incompletely understood symptom of various inborn errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model for studying glucose production ex vivo. This study quantified the net glucose production of human and murine PCLS in the presence of different gluconeogenic precursors.
View Article and Find Full Text PDFThe urinary metabolite tetraglucoside (Glc4) is a potential biomarker for hepatic glycogen storage diseases (GSDs). Glc4 is believed to reflect body glycogen content and/or turnover. However, dietary polysaccharide intake may influence Glc4 excretion, potentially limiting the utility of Glc4 as a monitoring biomarker in hepatic GSDs.
View Article and Find Full Text PDFContinuous glucose monitoring metrics in people with liver glycogen storage disease and idiopathic ketotic hypoglycemia: A single-center, retrospective, observational study.
Mol Genet Metab
October 2024
Background: Cohort data on continuous glucose monitoring (CGM) metrics are scarce for liver glycogen storage diseases (GSDs) and idiopathic ketotic hypoglycemia (IKH). The aim of this study was to retrospectively describe CGM metrics for people with liver GSDs and IKH.
Patients And Methods: CGM metrics (descriptive, glycemic variation and glycemic control parameters) were calculated for 47 liver GSD and 14 IKH patients, categorized in cohorts by disease subtype, age and treatment status, and compared to published age-matched CGM metrics from healthy individuals.
No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha-fetoprotein and carcino-embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des-gamma-carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation.
View Article and Find Full Text PDFArticle Synopsis
- - The study looked at how air pollution and green space affect cardiometabolic risk in Dutch children aged 5 to 17, using data from three large cohorts totaling 13,822 participants.
- - Researchers used statistical models to analyze the impact of air pollutants like nitrogen oxides (NO) and elemental carbon (EC) on cardiometabolic health, finding that higher levels of these pollutants were linked to increased health risks in one of the cohorts.
- - The study also explored the relationship between green space density and health, discovering that more green space in wider areas (2000 meters) was associated with lower health risk scores in two of the cohorts, while no significant relationship was found in smaller areas (500 meters).