Publications by authors named "A Marsland"
Introduction: Blood-based biomarkers (BBMs) can enable early detection of brain amyloid beta (Aβ) pathology in cognitively unimpaired individuals. However, the extent to which common medical conditions affect biomarker performance remains unclear.
Methods: Participants (n = 348) included individuals without cognitive impairment.
Importance: Emerging evidence suggests that severe acute respiratory syndrome, COVID-19, negatively impacts brain health, with clinical magnetic resonance imaging (MRI) showing a wide range of neurologic manifestations but no consistent pattern. Compared with 3 Tesla (3T) MRI, 7 Tesla (7T) MRI can detect more subtle injuries, including hippocampal subfield volume differences and additional standard biomarkers such as white matter lesions. 7T MRI could help with the interpretation of the various persistent post-acute and distal onset sequelae of COVID-19 infection.
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- - The study compares brain imaging results from 3 Tesla (3T) and 7 Tesla (7T) MRI to assess differences in brain morphology, focusing on signal quality and accuracy issues associated with each technology.
- - Using data from 452 healthy participants, the research employed FreeSurfer for brain segmentation, explored normalization methods for accounting variability in head size, and correlated brain measurements with age.
- - Findings indicate that 7T MRI provided stronger correlations between brain structure and age, although different normalization techniques impacted the results for 3T, with the Residual method showing better age correlation compared to the Proportional method.
Objective: The Exercise Program in Cancer and Cognition (EPICC) Study was a randomized controlled trial (RCT) designed to determine whether six months of moderate-intensity aerobic exercise improves neurocognitive function in women with breast cancer (BC) receiving endocrine therapy (ET).
Methods: Postmenopausal women with hormone receptor+, early-stage BC, within two years post-primary therapy were randomized to the exercise intervention (six months, ≥150 minutes of moderate-intensity aerobic exercise/week) or usual care control condition. Outcomes were assessed at pre-randomization and after intervention completion.