Publications by authors named "A Markoe"
Introduction: Iodine-125 brachytherapy is an effective eye-sparing treatment for uveal melanoma. Previous work has shown that uveal melanomas cluster into distinct molecular classes based on gene expression profiles - discriminating low-grade from high-grade tumors. Our objective was to identify clinical and molecular predictors of local recurrence (LR) and progression-free survival (PFS).
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- This study examines the effects of brachytherapy, a treatment for medium-sized uveal melanomas, focusing on identifying factors that predict radiation toxicities (RTT) such as radiation maculopathy and optic neuropathy.
- A retrospective review of 258 patients treated between 2011 and 2019 revealed significant associations between RTT and factors like shorter distance to fovea, exudative retinal detachment, and vitreous hemorrhage.
- The research highlights that female patients and those with higher tumor height are at greater risk for specific complications, providing valuable prognostic information for counseling patients undergoing treatment.
Comprehensive information on clinical features and long-term outcomes of primary conjunctival extranodal marginal zone lymphoma (PCEMZL) is scarce. We present a large single-institution retrospective study of 72 patients. The median age was 64 years, and 63.
View Article and Find Full Text PDFPurpose: Tilting of the posterior plaque margin during eye plaque brachytherapy can lead to tumor underdosing and increased risk of local recurrence. We performed a quantitative analysis of the dosimetric effects of plaque tilt as a function of tumor position, basal dimension, height and plaque type using 3D treatment planning software.
Materials And Methods: Posterior and anterior tumors with largest basal dimensions of 6, 12 and 18 mm and heights of 4, 7 and 10 mm were modeled.
Neurologic symptoms from leukemic infiltration of the central nervous system are an oncologic emergency, and expeditious treatment is required to preserve function. We report the case of a 44-year-old patient with relapsed acute myeloid leukemia (AML) who developed sub-acute cranial neuropathies refractory to treatment with intrathecal (IT) chemotherapy. The patient was therefore treated with an emergent course of whole-brain radiotherapy, resulting in immediate improvement and subsequent resolution of cranial neuropathies.
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