TBK1 is involved in programmed cell death and ALS-related pathways in novel zebrafish models.

Pathogenic mutations within the TBK1 gene leading to haploinsufficiency are causative of amyotrophic lateral sclerosis (ALS). This gene is linked to autophagy and inflammation, two cellular mechanisms reported to be dysregulated in ALS patients, although its functional role in the pathogenesis could involve other players. We targeted the TBK1 ortholog in zebrafish, an optimal vertebrate model for investigating genetic defects in neurological disorders.

An open letter to the NIH cardiovascular study section reviewers.

The reviewers who serve at the National Institute of Health (NIH) study sections are in the unique position of identifying the most scientifically meritorious grant applications for consideration for funding. Consequently, the reviewers guide the direction of scientific discoveries in the US, which ultimately translate to patient care. Recently many investigators have expressed concerns about the quality of the reviews that they received from the National Heart, Lung, and Blood Institute (NHLBI) study section reviewers.

Incorrectly Charted Operating Rooms, With Resulting Overlapping Times, Corrected Using Meta-Data From Monitors Transmitting Pulse Oximetry Measurements.

Recorded operating rooms (ORs) in electronic health records can differ from the actual anesthetizing locations. A retrospective cohort of cases revealed a 40% (846/2123) room location error rate in the obstetrical (OB) suite compared to 0.03% (18/56,044) in 3 large surgical suites.

Domain-specific association of single-nucleotide variants in the LMNA gene with the phenotypic expression of dilated cardiomyopathy.

Background: LMNA gene variants cause a spectrum of phenotypes referred to as laminopathies. However, the topological distribution of the LMNA variants and their phenotypic effects have not been delineated. We investigated the associations of variants located at different LMNA domains with clinical phenotypes in dilated cardiomyopathy (DCM) patients.

Economic impact of prolonged tracheal extubation times on operating room time overall and for subgroups of surgeons: a historical cohort study.

Background: Prolonged tracheal extubation time is defined as an interval ≥ 15 min from the end of surgery to extubation. An earlier study showed that prolonged extubations had a mean 12.4 min longer time from the end of surgery to operating room (OR) exit.