Publications by authors named "A Margeli"
This is a SARS-CoV-2 seroepidemiological study in a pediatric population (0-16 years) during the BA.5 Omicron predominance period in the Athens metropolitan area. Serum samples were tested for SARS-CoV-2 nucleocapsid antibodies (Abs-N), representing natural infection during three periods of BA.
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- YKL-40 shows potential as a diagnostic biomarker for sepsis in term neonates, with significantly elevated levels during the acute phase of infection compared to remission and controls.
- A pilot study with 45 term neonates found that YKL-40 levels correlated positively with other inflammatory markers like white blood count and CRP levels, indicating its role in sepsis diagnosis.
- ROC analysis revealed that YKL-40 is a significant indicator of sepsis upon admission, suggesting it could serve as an adjuvant biomarker alongside existing methods.
Prematurity has been linked with endothelial dysfunction in later life. The purpose of this study was to evaluate the association between plasma irisin, an adipomyokine reported to protect the functional integrity of vascular endothelium, and circulating endothelial microparticles (EMPs) and endothelial progenitor cells (EPCs), consisting early biomarkers of endothelial dysfunction, in preterm-born children. We studied 131 prepubertal children; 61 preterm and 70 born at term (controls).
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- The study examined the prevalence of SARS-CoV-2 antibodies in children during periods dominated by the Delta and Omicron variants, showing a rise in seropositivity from 29.7% to 48.5% as the Omicron variant emerged.
- A total of 506 out of 1312 children tested were found to be seropositive, with the highest rates observed in older adolescents (73.9% in ages 12-16).
- No significant differences were found in seropositivity based on gender, origin, or hospitalization status, but antibody levels were notably higher during the Omicron period, particularly in adolescents.
Limited prospective serosurveillance data in children regarding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been reported. We prospectively investigated SARS-CoV-2 seropositivity in children during a 16-month period of the coronavirus disease 2019 (COVID-19) pandemic, including the four waves of the pandemic, before SARS-CoV-2 adolescents' vaccination. Serum samples from children admitted to the major tertiary Greek pediatric hospital for any cause, except for COVID-19 infection, were randomly collected from 05/2020 to 08/2021.
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