Publications by authors named "A Mardirossian"
Porcine astrovirus 4 (PoAstV4) has been recently associated with respiratory disease in pigs. In order to understand the scope of PoAstV4 infections and to support the development of a vaccine to combat PoAstV4 disease in pigs, we designed and produced a recombinant PoAstV4 capsid spike protein for use as an antigen in serological assays and for potential future use as a vaccine antigen. Structural prediction of the full-length PoAstV4 capsid protein guided the design of the recombinant PoAstV4 capsid spike domain expression plasmid.
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- * A comprehensive review of literature from January 2000 to October 2020 identified 334 articles that reported 455 SNPs related to BC; however, those linked to smoking and environmental factors were excluded.
- * Ultimately, 197 genes and 343 SNPs were associated with BC, with 177 genes and 291 SNPs showing consistent findings across various studies, categorized into eight functional groups.
Article Synopsis
- Bladder cancer (BC) is the 10th most common cancer worldwide and is particularly prevalent in Lebanon, but the genetic factors contributing to this high incidence among Lebanese are not well understood.
- A case-control study involving 51 patients at Hotel-Dieu de France Hospital used Whole Exome Sequencing (WES) to identify potentially cancer-associated genetic variants, comparing these findings to a control group of 472 Lebanese individuals.
- The study identified 484 polymorphisms linked to BC, with significant differences in allelic frequencies for 11 variants, but none were associated with an increased risk of BC in the Lebanese population, including a specific variant in the NAT1 gene.
Background/aims: Human herpesvirus-associated diseases exhibit elevated morbidity and mortality in patients infected with human immunodeficiency virus (HIV). This study aimed to investigate the occurrence of herpesviruses in HIV-periodontitis.
Method: Gingival biopsies from periodontitis lesions of 21 HIV-patients and 14 non HIV-patients were studied.
Herpesviruses 6, 7 and 8 in HIV- and non-HIV-associated periodontitis.
J Periodontal Res
October 2000
Human herpesviruses, especially cytomegalovirus and Epstein Barr virus type-1, occur with higher frequency in subgingival specimens from periodontitis lesions than from healthy/gingivitis sites. Little or no information is available on the relationship between herpesvirus 6 (HHV-6), herpesvirus 7 (HHV-7) and herpesvirus 8 (HHV-8) and periodontal disease. This study determined the periodontal occurrence of HHV-6, HHV-7 and HHV-8 in 21 HIV-seropositive and 14 HIV-negative adults affected by periodontitis.
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