Publications by authors named "A Marano"
Here, we report the X-ray structure of the adduct formed upon reaction of cisplatin, one of the most prescribed anticancer agents for the clinic treatment of solid tumors, with the apo-form of human serum transferrin (hTF). Two Pt binding sites were identified in both molecules of the adduct present in the crystal asymmetric unit: Pt binds close to the side chains of Met256 and Met499 at the N- and C-lobe, respectively. In the crystal structure, the cisplatin moiety bound to Met256 also interacts with Ser616 from a symmetry related molecule.
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- The human body produces catecholamine neurotransmitters like dopamine, adrenaline, and cortisol during stress, making their levels important for stress management and medical use.
- A new analytical device has been developed that can simultaneously detect these three molecules in human saliva without needing any pre-treatments.
- The device uses a sensor array with fluorescent chemical receptors, demonstrating high accuracy and selectivity over a concentration range of 1 pM to 1 mM, marking it as the first point-of-care tool for this type of measurement in saliva.
Article Synopsis
- Nonampullary duodenal adenocarcinoma (NDA) is a rare type of gastrointestinal cancer that requires complete surgical removal for potential cure and long-term survival.
- This study introduces a fully laparoscopic method for surgically removing left-side NDA while preserving critical safety measures and ensuring complete resection and lymph node removal.
- The paper aims to provide guidance and enhance surgeons' skills in performing this minimally invasive and complex surgical procedure.
Studies on the molecular mechanisms of heavy metal toxicity in invertebrate reproduction are limited. Given that PARP-catalysed ADP-ribosylation is also involved in counteracting heavy metal toxicity and maintaining genomic integrity, and that PARylation is implicated in chromatin remodelling but its role in sperm chromatin remains to be elucidated, we investigated the effects of chromium(VI) at 1, 10 and 100 nM on the reproductive health of Mytilus galloprovincialis. The damage to the gonads was assessed by morphological analyses and the damage indices PARP and ɣH2A.
View Article and Find Full Text PDFBackground: The COVID-19 pandemic prompted surgical volume reductions due to lockdown measures. This study evaluates COVID-19's impact on gender-affirming surgery (GAS) volume and complications from the pandemic onset through the recovery period.
Methods: The 2019-2021 National Surgical Quality Improvement Program databases were queried for transgender or gender-diverse patients using ICD-10 codes.