Publications by authors named "A Marabotti"
Establishing an Extracorporeal Cardiopulmonary Resuscitation Program.
Medicina (Kaunas)
December 2024
Extracorporeal cardiopulmonary resuscitation (ECPR) is a complex, life-saving procedure that uses mechanical support for patients with refractory cardiac arrest, representing the pinnacle of extracorporeal membrane oxygenation (ECMO) applications. Effective ECPR requires precise patient selection, rapid mobilization of a multidisciplinary team, and skilled cannulation techniques. Establishing a program necessitates a cohesive ECMO system that promotes interdisciplinary collaboration, which is essential for managing acute cardiogenic shock and severe pulmonary failure.
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- The meta-analysis reviews the effectiveness of veno-venous extracorporeal membrane oxygenation (VV-ECMO) in treating severe ARDS among COVID-19 versus non-COVID patients.
- It analyzed 24 studies involving 2,121 patients, finding that non-COVID ARDS patients had a lower mortality risk compared to those with COVID-19 ARDS and required ECMO for longer durations if they had COVID-19.
- The findings emphasize the need for tailored ECMO strategies based on the viral cause of ARDS to improve clinical outcomes and resource management in current and future health crises.
Article Synopsis
- Extracorporeal cardiopulmonary resuscitation (ECPR) can improve survival rates in patients with refractory cardiac arrest, but results on neurological outcomes are inconsistent.
- A study analyzing 9 cohort studies with nearly 5,000 patients found that combining ECPR with an intra-aortic balloon pump (IABP) significantly improved survival rates (32.9% vs. 20.2%).
- While there was a trend toward better neurological outcomes with ECPR+IABP, the results weren't statistically significant, emphasizing the need for further research in this area.
Insights Into Perioperative Hypertension Management in Europe: Results From a Survey Endorsed by the European Association of Cardiothoracic Anaesthesiology and Intensive Care (EACTAIC).
J Cardiothorac Vasc Anesth
December 2024
Article Synopsis
- The study aimed to understand how perioperative hypertension is managed in Europe, given the lack of agreement on blood pressure targets.
- An online survey involving 339 participants (mostly anesthesiologists) revealed most aim for systolic blood pressure (SBP) between 120-140 mmHg during surgeries.
- Common medications used include α-adrenoreceptor antagonists, nitrates, and calcium channel blockers, with a preference for those that allow titratable control; less than 20% of procedures experienced treatment failures.
Eotaxin-3 is a key chemokine with a relevant role in eosinophilic esophagitis, a rare chronic immune/antigen-mediated inflammatory disorder. Eotaxin-3 is a potent activator of eosinophil emergence and migration, which may lead to allergic airway inflammation. We investigated, using bioinformatics tools, the protein structure and the possible effects of the known variations reported in public databases.
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