Quality of life in Spanish postmenopausal breast cancer patients with localized disease who finish endocrine treatment: a prospective study.

Objective: In this article, the quality of life (QOL) of Spanish postmenopausal early-stage breast cancer patients who have finished endocrine therapy (ET), QOL changes after endocrine therapy cessation, and the differences between two endocrine therapy modalities (tamoxifen or aromatase inhibitor [AI]) are studied. More QOL information after endocrine therapy cessation is needed.

Methods: A prospective cohort study was performed.

Quality of life of early-stage breast-cancer patients diagnosed with COVID-19 in the first three waves of the epidemic treated in the Spanish region of Navarre.

Objectives: To describe the Quality of Life (QOL) of breast-cancer patients diagnosed with COVID-19 and analyse its evolution, compare the QOL of these patients according to the COVID-19 wave in which they were diagnosed, and examine the clinical and demographic determinants of QOL.

Methods: A total of 260 patients with breast cancer (90.8% I-III stages) and COVID-19 (85% light/moderate) were included (February-September 2021) in this study.

Cannabinoid CB receptor expression in oligodendrocyte progenitors of the hippocampus revealed by the NG2-EYFP-knockin mouse.

Adult oligodendrocyte progenitor cells (OPCs) give rise to myelinating oligodendrocytes through life and play crucial roles in brain homeostasis and plasticity during health and disease. Cannabinoid compounds acting through CB receptors promote the proliferation and differentiation of OPCs and facilitate developmental myelination and myelin repair . However, CB receptor expression in adult OPCs has not been corroborated by anatomical studies and the contribution of this receptor population to the (re)myelination effects of cannabinoids remains a matter of debate.

Endocannabinoid signaling in brain diseases: Emerging relevance of glial cells.

The discovery of cannabinoid receptors as the primary molecular targets of psychotropic cannabinoid Δ -tetrahydrocannabinol (Δ -THC) in late 1980s paved the way for investigations on the effects of cannabis-based therapeutics in brain pathology. Ever since, a wealth of results obtained from studies on human tissue samples and animal models have highlighted a promising therapeutic potential of cannabinoids and endocannabinoids in a variety of neurological disorders. However, clinical success has been limited and major questions concerning endocannabinoid signaling need to be satisfactorily addressed, particularly with regard to their role as modulators of glial cells in neurodegenerative diseases.

Magnetization Reversal Process and Magnetostatic Interactions in FeCo/SiO/FeO Core/Shell Ferromagnetic Nanowires with Non-Magnetic Interlayer.

Nowadays, numerous works regarding nanowires or nanotubes are being published, studying different combinations of materials or geometries with single or multiple layers. However, works, where both nanotube and nanowires are forming complex structures, are scarcer due to the underlying difficulties that their fabrication and characterization entail. Among the specific applications for these nanostructures that can be used in sensing or high-density magnetic data storage devices, there are the fields of photonics or spintronics.