Publications by authors named "A Manova"
Wire Electrical Discharge Machining (WEDM) technology represents an unconventional but vital manufacturing technology in many different industrial branches. The automotive industry and its many significant requirements bring the need to manufacture inserts and mould segments for plastic injections from Albromet W130 material, with a required roughness, Ra, from 4.5 to 5 µm so that subsequent profile etching can be eliminated.
View Article and Find Full Text PDFPharmacokinetics of PEGylated Gold Nanoparticles: In Vitro-In Vivo Correlation.
Nanomaterials (Basel)
February 2022
Article Synopsis
- Data for creating physiologically-based pharmacokinetic (PBPK) models for nanoparticles (NPs) is limited, leading researchers to rely on in vitro and in silico studies for hazard assessment.
- A pharmacokinetic study using polyethylene glycol-coated gold nanoparticles (PEG-AuNPs) was conducted both in vitro with various human cell lines and in vivo with rats to compare biodistribution.
- Significant differences were found between the amounts of nanoparticles absorbed by individual cell lines and tissues in vivo, primarily due to the lack of biological barriers in in vitro testing, suggesting that caution is needed when using in vitro data for in vivo predictions.
Despite the obvious advantages of gold nanoparticles for biomedical applications, controversial and incomplete toxicological data hamper their widespread use. Here, we present the results from an in vivo toxicity study using gold nanoparticles coated with polyethylene glycol (PEG-AuNPs). The pharmacokinetics and biodistribution of PEG-AuNPs were examined in the rat's liver, lung, spleen, and kidney after a single i.
View Article and Find Full Text PDFWe demonstrate specific interface-templated crystallization behavior of biocompatible amphiphilic poly(ethylene oxide)--poly(ε-caprolactone) (PEO--PCL) block copolymers enabling triggered shaping of the curvature of the oil/water interface and controlled phase inversion, including the formation of stable multiple emulsions. Water-born anisotropic micelles of PEO--PCL block copolymers self-assemble at the oil-water interface in a multilayer form and undergo conformational rearrangements into unique semicrystalline multilamellar shells, for which curvature (type of emulsion) can be tuned by the molecular architecture (volume fractions of the blocks) and/or by the temperature. The latter trigger affects both the solubility of the PEO block in water and the semicrystalline state of the PCL block.
View Article and Find Full Text PDFAim: The purpose of this study was to establish the validity of abdominal sonographic evaluation of lower uterine segment (LUS) thickness in full-term pregnancies with a single previous cesarean section, and to assess the usefulness of measuring LUS thickness in predicting the risk of uterine dehiscence.
Methods: Three hundred and thirty-six women with a single previous cesarean section who had an ultrasound measurement of the LUS thickness in pregnancy were enrolled. Abdominal sonographic assessment of LUS was carried out within 2 weeks of delivery.