Publications by authors named "A Mangolini"

Introduction: The transdiagnostic approach has been shown to offer promising prospects in psychopathology, based on the observation that common factors may be involved in different psychiatric disorders. The transdiagnostic skills scale (T2S) was developed recently to assess the skills that are disrupted in these disorders. However, studies have shown that the T2S has lower predictive power for externalizing than internalizing disorders.

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The application of liposomes (LPs) to central nervous system disorders could represents a turning point in the therapy and quality of life of patients. Indeed, LPs have demonstrated their ability to cross the blood-brain barrier (BBB) and, as a consequence, to enhance the therapeutics delivery into the brain. Some approaches for BBB crossing involve the modification of LP surfaces with biologically active ligands.

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Introduction: The categorical approach in psychiatry has received many criticisms. Modern research tends to develop a transdiagnostic approach. However, transdiagnostic works lack an overall understanding and focus mainly on anxiety and depression.

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Introduction: Psychotherapy has proved its efficacy for treating a wide range of psychological disorders. Most types of psychotherapy have been developed to treat specific disorders and validated through controlled-randomized trials. In recent years, researchers have developed a new way to conceptualize patients' difficulties, focusing on processes instead of diagnoses.

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Article Synopsis
  • Gene mutations can influence tumor development and treatment choices in prostate cancer (PCa), highlighting the importance of mutation research for better patient care.
  • A study analyzed genomic DNA from 48 PCa samples and identified 312 significant mutations, mostly single nucleotide variants, with key genes like KMT2D and TP53 showing a strong association with prognosis.
  • The findings suggest that specific mutations, including some linked to hereditary cancer syndromes, could serve as valuable prognostic markers to enhance treatment strategies for PCa patients.
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