Publications by authors named "A Mangogna"
Endometriosis is a chronic inflammatory condition characterized by the presence of endometrium-like tissue outside the uterus, primarily affecting pelvic organs and tissues. In this study, we explored platelet activation in endometriosis. We utilized the STRING database to analyze the functional interactions among proteins previously identified in small extracellular vesicles (EVs) isolated from the peritoneal fluid of endometriosis patients and controls.
View Article and Find Full Text PDFHuman C1q is a multifaceted complement protein whose functions range from activating the complement classical pathway to immunomodulation and promoting placental development and tumorigenesis. It is encoded by the , , and genes located on chromosome 1. C1q, unlike most complement components, has extrahepatic expression by a range of cells including macrophages, monocytes and immature dendritic cells.
View Article and Find Full Text PDFBackground: Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan that can be considered as useful target for glioblastoma multiforme (GBM) treatment being specifically and highly expressed on GBM cell surface. Here, we proposed the use of AT101 as targeting agent in a drug delivery nanoplatfom to effectively deliver chitosan nanobubbles (NBs) for GBM treatment.
Methods: Chitosan NBs were prepared and conjugated with AT101 or left unconjugated as control.
Article Synopsis
- Early detection of recurrences in gynecological cancers is vital, and circulating tumor DNA (ctDNA) analysis via liquid biopsy shows promise for monitoring disease progression.
- The study assessed the effectiveness of digital Polymerase Chain Reaction (dPCR) in detecting ctDNA in three patients with confirmed cancer relapses post-surgery, using patient-specific mutations identified through whole-exome sequencing.
- Results indicated that dPCR could detect increased ctDNA levels before traditional serum markers like CA125, but also highlighted the challenges of tumor heterogeneity, as one patient did not show ctDNA signals despite clinical signs of relapse.
Malignant pleural mesothelioma (MPM) represents a significant clinical challenge due to limited therapeutic options and poor prognosis. Beyond mere survivorship, setting up an effective framework to improve functioning and quality of life is an urgent need in the comprehensive management of MPM patients. Therefore, this study aims to review the current understanding of MPM sequelae and the effectiveness of rehabilitative interventions in the holistic approach to MPM.
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