Publications by authors named "A Mangklabruks"
Per- and polyfluoroalkyl substances (PFAS) are widely detected in pregnant persons and can be transferred to the developing fetus in utero. Breastfeeding may represent an important source of PFAS exposure for infants. However, studies quantifying levels of PFAS in breastmilk samples remain scarce, particularly in low- and middle-income countries.
View Article and Find Full Text PDFBackground: Maternal obesity is associated with an increased risk of large-for-gestational-age births and childhood obesity. However, evidence on its potential associations with long-term offspring body composition remains limited. This prospective cohort study examined associations between maternal body mass index (BMI) during pregnancy and body composition in the young adult offspring.
View Article and Find Full Text PDFThis study aims to explore the effect in each stage of chronic kidney disease (CKD) on the major adverse cardiovascular events (MACE) in diabetes mellitus (DM) patients with peripheral arterial disease (PAD). A total of 246 DM patients with diagnosed PAD were enrolled in this study. Of these, 86 patients (35%) died and 34 patients had non-fatal cardiovascular events occurred at the last 7 years follow-up.
View Article and Find Full Text PDFBackground: In animal models, prenatal zinc deficiency induced epigenetic changes in the fetus, but data in humans are lacking. We aimed to examine associations between maternal zinc levels during pregnancy and DNA methylation in LINE-1 and Alu repetitive sequences in young adult offspring, as well as anthropometry and cardiometabolic parameters.
Methods: Participants were 74 pregnant women from the Chiang Mai Low Birth Weight cohort, and their offspring followed up at 20 years of age.
Article Synopsis
- Organophosphate insecticides, like chlorpyrifos, pose potential risks to maternal and child health, but research on their biological effects during pregnancy is limited.
- A study conducted on 50 pregnant women in Thailand used advanced metabolic profiling techniques to evaluate the impact of chlorpyrifos exposure by measuring a specific urinary metabolite (TCPy) and identifying linked metabolic changes.
- Results revealed a median urinary TCPy level of 4.36 μg/g creatinine and identified 691 unique metabolic features associated with TCPy, with significant pathway disruptions linked to oxidative stress and cellular damage, such as tryptophan metabolism and fatty acid oxidation.