Role of peroxisome proliferator-activated receptors α and γ in mediating the beneficial effects of β-caryophyllene in a rat model of fragile X syndrome.

β-Caryophyllene (BCP) is a naturally occurring sesquiterpene found in numerous plant species, including Cannabis sativa. BCP has shown a high safety profile and a wide range of biological functions, including beneficial effects in neurodegenerative and inflammatory diseases. Here, we used behavioral, pharmacological, and in-silico docking analyses to investigate the effects and mechanism of action of BCP in Fragile X Syndrome (FXS), the most common inherited cause of Autism Spectrum Disorder (ASD) and intellectual disability.

MR elastography-based detection of impaired skull-brain mechanical decoupling performance in response to repetitive head impacts.

Objective: To evaluate MR elastography (MRE)-assessed biomarkers for detecting changes in skull-brain mechanical decoupling performance induced by repetitive head impacts (RHIs).

Methods: This prospective single-center study enrolled 80 asymptomatic participants (2017-2023) divided into three groups: no exposure (RHI(-)), low-impact (low RHI(+)), and high-impact (high RHI(+)). Four MRE-based parameters were evaluated to analyze the skull-brain decoupling performance: brain-to-skull rotational transmission ratio (Rtr), cortical shear strain (normalized OSS (octahedral shear strain)), cortical volumetric strain (normalized ONS (octahedral normal strain)), and the OSS-to-ONS ratio.

Acquisition Efficiency and Technical Repeatability of Dual-Frequency 3D Vector MR Elastography of the Liver.

Background: MR elastography (MRE) at 60 Hz is widely used for staging liver fibrosis. MRE with lower frequencies may provide inflammation biomarkers.

Purpose: To establish a practical simultaneous dual-frequency liver MRE protocol at both 30 Hz and 60 Hz during a single examination and validate the occurrence of second harmonic waves at 30 Hz.

Improved quantification of tumor adhesion in meningiomas using MR elastography-based slip interface imaging.

Meningiomas, the most prevalent primary benign intracranial tumors, often exhibit complicated levels of adhesion to adjacent normal tissues, significantly influencing resection and causing postoperative complications. Surgery remains the primary therapeutic approach, and when combined with adjuvant radiotherapy, it effectively controls residual tumors and reduces tumor recurrence when complete removal may cause a neurologic deficit. Previous studies have indicated that slip interface imaging (SII) techniques based on MR elastography (MRE) have promise as a method for sensitively determining the presence of tumor-brain adhesion.