Publications by authors named "A Mamdouh"
Article Synopsis
- Prostate cancer (PC) is a common and serious cancer in men, but current diagnostic methods like biopsies have drawbacks in invasiveness and accuracy.
- This study introduces a machine learning technique that uses clinical data and personalized questionnaires to improve PC diagnosis, employing various advanced methods including CNNs for tabular data analysis.
- The proposed approach shows impressive results with an F1-score of 0.907 and AUC of 0.911, indicating a potential for accurate PC detection without invasive and expensive tests.
Article Synopsis
- In many cancers, including acute myeloid leukemia (AML), the challenge of relapse often involves multidrug resistance (MDR) linked to changes in cancer cell genetics.
- Researchers employed acute myeloid leukemia patient-derived xenografts (PDX) to explore drug sensitivity and resistance mechanisms, revealing that resistance often correlates with diminished mitochondrial apoptotic priming and affects responses to various drug types.
- Their findings suggest that by using dynamic BH3 profiling (DBP), it's possible to identify effective drugs for patients experiencing drug-resistant relapses, highlighting the potential for this method in developing personalized treatment strategies.
Background: Correlative interactions between electrical charges and cancer cells involve important unknown factors in cancer diagnosis and treatment. We previously reported the intrinsic suppressive effects of pure positive electrostatic charges (PEC) on the proliferation and metabolism of invasive cancer cells without any effect on normal cells in cell lines and animal models. The proposed mechanism was the suppression of pro-caspases 3 and 9 with an increase in Bax/Bcl2 ratio in exposed malignant cells and perturbation induced in the KRAS pathway of malignant cells by electrostatic charges due to the phosphate molecule electrostatic charge as the trigger of the pathway.
View Article and Find Full Text PDFFlaxseed (Linum usitatissimum L) is an ancient perennial plant species regarded as a multipurpose plant owing to its richness in omega-3 polyunsaturated fatty acids (PUFA) including α-linolenic acid (ALA). The extensive biochemical analysis of flaxseed resulted in the identification of its bioactive, i.e.
View Article and Find Full Text PDFPure positive electrostatic charges (PPECs) show suppressive effect on the proliferation and metabolism of invasive cancer cells without affecting normal tissues. PPECs are used for the delivery of drug-loaded polymeric nanoparticles (DLNs) capped with negatively charged poly(lactide-co-glycolide) (PLGA) and Poly(vinyl-alcohol) PVA into the tumor site of mouse models. The charged patch is installed on top of the skin in the mouse models' tumor region, and the controlled selective release of the drug is assayed by biochemical, radiological, and histological experiments on both tumorized models and normal rats' livers.
View Article and Find Full Text PDF