Publications by authors named "A Malogolovkin"
Article Synopsis
- The goose parvovirus (GPV) causes severe disease in young geese and ducks, leading to high mortality rates of 70-100% in naive groups, resulting in major losses for farmers.
- A study investigated the historical virulent GPV LIV-22 strain from 1972 and a developed attenuated vaccine strain, showing both belong to the classical GPV group but exhibit unique genetic changes.
- Microscopic analysis revealed significant cellular damage in infected geese shortly after exposure, providing insights into how GPV evolves and causes disease, which can aid future research on GPV's molecular pathogenesis.
Background: African swine fever (ASF) is a viral disease that affects pigs and wild boars providing economic burden in swine industry.
Methods And Results: In this study, we investigated the effect of deleting the ASFV multigene family 110 (MGF110) fragment (1 L-5-6 L) on apoptosis modulation and the expression of proinflammatory cytokines. Gene expression in swine peripheral blood macrophages infected with either the parental "Volgograd/14c" strain or the gene-deleted "Volgograd/D(1L-5-6L) MGF110" strain was analyzed.
One of the well-known X-linked genetic disorders is hemophilia, which could be hemophilia A as a result of a mutation in the (factor VIII) gene or hemophilia B as a result of a mutation in the (factor IX) gene, leading to insufficient levels of the proteins essential for blood coagulation cascade. In patients with severe hemophilia, factor VIII or factor IX activities in the blood plasma are considerably low, estimated to be less than 1%. This is responsible for spontaneous or post-traumatic bleeding episodes, or both, leading to disease complications and death.
View Article and Find Full Text PDFMyxoma virus (MYXV) is a double-stranded DNA-containing virus of the family Poxviridae, genus Leporipoxvirus. MYXV is an important model virus for evolutionary and immunological research and a promising oncolytic. In this study, we sequenced and analyzed two complete genomes of MYXV virus vaccine strains B-82 and Rabbivac-B, which are widely used for vaccine production in Russia.
View Article and Find Full Text PDFThe design of new effective cancer treatment methods is a promising and important research field in translational medicine. Oncolytic viruses can induce immunogenic cell death by activating the body's immune system to recognize tumor cells. This work presents the results for optimizing the production of recombinant vesicular stomatitis viruses (rVSVs).
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