Auto-adjusted versus fixed positive airway pressure in patients with severe OSA: A large randomized controlled trial.

Background And Objective: Continuous positive airway pressure (CPAP) in the treatment of severe obstructive sleep apnoea (OSA) can be used in fixed CPAP or auto-adjusted (APAP) mode. The aim of this prospective randomized controlled clinical study was to evaluate the 3 month-efficacy of CPAP used either in fixed CPAP or APAP mode.

Methods: Eight hundred one patients with severe OSA were included in twenty-two French centres.

Factors impacting performance on the 6-minute walk test by people with late-onset Pompe disease.

Introduction/aims: Pompe disease is a progressive myopathy that combines motor, respiratory, and cardiac impairments. The 6-min walk test is the gold standard for assessing disease severity at the motor level. The objective of this study was to better determine the parameters that influence the total distance covered in patients with Pompe disease.

Influence of nocturnal hypoxemia on follow-up course after type B acute aortic syndrome.

Introduction: Association between sleep nocturnal breathing disorders and acute aortic syndrome (AAS) has been described but mid-term data are scarce.

Objectives: We assessed the prognostic value of sleep apnea parameters and their relationship with aortic morphology after the onset of a type B AAS.

Methods: Between January 2010 and January 2018, sleep apnea screening in post type B AAS was prospectively performed.

Dramatic impact of morbid obesity on child lung development.

Objective: To assess the respiratory function and sleep characteristics of obese adults and children.

Methods: All patients with non-syndromic, severe obesity (BMI ≥3 z-scores for children and ≥40.00kg/m for adults), referred for pulmonary function tests at Lille University Hospital, were retrospectively included.

Sex differences in mandibular repositioning device therapy effectiveness in patients with obstructive sleep apnea syndrome.

Purpose: Mandibular repositioning devices (MRDs) are an effective treatment option for obstructive sleep apnea syndrome (OSAS), particularly in patients who refuse or cannot tolerate continuous positive airway pressure (CPAP). However, sex differences in the response to therapy and predictors of response are not clearly defined. This analysis of data from the long-term prospective ORCADES trial compared MRD efficacy in men and women with OSAS.