Publications by authors named "A Malet Llado"
Background And Objectives: Pathogenic variants in the gene cause frontotemporal dementia (FTD-) with marked brain asymmetry. This study aims to assess whether the disease progression of FTD- depends on the initial side of the atrophy. We also investigated the potential use of brain asymmetry as a biomarker of the disease.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a modified script training intervention called Video-Implemented Script Training for Aphasia (VISTA) aimed at improving speech in people with Primary Progressive Aphasia (PPA), a disorder that affects language skills.
- Thirteen bilingual participants (Spanish-Catalan) with different variants of PPA underwent the training over 8 weeks, with evaluations on their script accuracy and production quality at multiple time points.
- Results indicated significant improvements in various speech measures regardless of whether the training was conducted via teletherapy or in-person, highlighting the effectiveness and acceptability of the intervention for individuals with different PPA variants.
Article Synopsis
- Neuroimaging and fluid biomarkers, like MRI and cerebrospinal fluid (CSF) analysis, help distinguish frontotemporal dementia (FTD) from Alzheimer's disease (AD).
- A machine learning algorithm was developed to calculate individual probabilistic scores, yielding an 82% accuracy rate for differentiating between AD and FTD using MRI alone.
- Combining MRI data with CSF biomarkers improved diagnostic accuracy and confidence, making the algorithm a promising tool for clinical use, especially in scenarios with limited access to expert diagnoses.
Article Synopsis
- Early-onset Alzheimer's disease (EOAD) has more severe neuropsychiatric symptoms and lower integrity of the locus coeruleus (LC) compared to late-onset Alzheimer's disease (LOAD).
- A study involving 104 subjects with AD and 32 healthy controls used MRI and other measurements to analyze the differences in LC integrity and symptoms between EOAD and LOAD.
- Results showed that EOAD's lower LC integrity correlates with increased neuropsychiatric symptoms, and its greater degeneration may explain these severe symptoms compared to LOAD.
Article Synopsis
- Wasteosomes (or corpora amylacea) are polyglucosan bodies linked to aging and neurodegenerative diseases, potentially serving a brain cleaning function.
- A study examined wasteosomes in 124 post-mortem FTLD patients across three proteinopathies (tau, TDP, and FUS), finding a higher accumulation in FTLD patients compared to controls, particularly in FTLD-FUS cases.
- Results indicated that while wasteosomes increased with disease duration in FTLD-TDP, they did not show this trend in FTLD-tau and FTLD-FUS, suggesting varying roles in disease progression among the proteinopathies.