'CoviSwift: A point-of-care RT-PCR device for SARS-CoV-2 and its variant detection.

We present the point-of-care (POC) molecular diagnostic solution, evaluated during COVID-19 pandemic caused by SARS-CoV-2 (Dec 2021). The POC comprised of a complete platform from self-sampling to RT-PCR testing of SARS-CoV-2 and its variants on portable Compact Q Real time polymerase chain reaction system. The multiplex assay was designed to target S, ORF1, and N genes of SARS-CoV-2 genome in a single tube with RNaseP as endogenous internal control.

Integration of tobacco cessation and tuberculosis management by NGOs in urban India: a mixed-methods study.

Tobacco use compromises tuberculosis (TB) treatment outcomes. Tobacco cessation is beneficial to TB patients at the individual level and from the perspective of a larger spectrum of non-communicable diseases associated with tobacco use. We assessed feasibility, effectiveness and provider perceptions on integrating brief tobacco cessation advice into routine TB care by DOTS providers from 27 TB treatment centres run by three non-governmental organisations (NGOs) in urban India.

EFFECTS OF VERAPAMIL ON DOPAMINE DEPENDENT BEHAVIOURS IN RATS.

Abstract : Verapamil at 5, 10 and 20 mg/kg ip did not inhibit the conditioned avoidance response, neither induced catalepsy nor antagonised apomorphine stereotypy in rats indicating that these doses do not block the postsynaptic striatal D 2 and D 1 dopamine (DA) receptors. However, pretreatment with 10 and 20 mg/kg ip verapamil potentiated methamphetamine stereotypy and antagonised catalepsy induced by small doses (0.05 and 0.